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KAKEN_16K13645seika.pdf
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Download
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:3.1 MB
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| Last updated |
:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 444
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ナノ粒子・生体分子のアクティブナノポア通過制御
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ナノリュウシ・セイタイ ブンシ ノ アクティブ ナノポア ツウカ セイギョ
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Nanoryūshi seitai bunshi no akutibu nanopoa tsūka seigyo
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Active control of nanopore translocation of nanoparticles and biomolecules
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斎木, 敏治
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サイキ, トシハル
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Saiki, Toshiharu
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慶應義塾大学・理工学部・教授
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Research team head
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科研費研究者番号 : 70261196
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桑原, 正史
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クワハラ, マサシ
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Kuwahara, Masashi
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国立研究開発法人産業技術総合研究所・電子光技術研究部門・上級主任研究員
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Research team member
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科研費研究者番号 : 60356954
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
ナノポア技術への期待はシーケンサ応用にとどまらず, 分子・粒子識別, タンパク分子解析や細胞観察・遺伝子導入などに広がりつつある。本研究では, 固体ナノポアに対してアクティブな制御機能を具備させることを目的とした。ナノポアを相変化材料で被覆し, 結晶相・アモルファス相間の大きな光学的コントラストを利用することによって, ナノポア近傍に生じる対流, 熱泳動を制御し, DNAやナノ粒子のナノポア通過過程のスイッチング機能を実証した。
Applications of nanopore technology are not limited to the DNA sequencing but also are extending to the molecular recognition, protein analysis, cell imaging, and gene transfer. The objective of this study is to implement active functionalities into the solid-state nanopore by employing a phase-change material. A huge contrast of optical indices between the crystalline and amorphous phases of phase-change material enabled control of convection flow and thermophoresis in the vicinity of nanopore by means of light irradiation. Switching of nanopore translocation of DNA molecules and nanoparticles was demonstrated.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2016～2017
課題番号 : 16K13645
研究分野 : ナノフォトニクス・光物性・バイオセンシング
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