The reference ranges of endocrine, lipid and chemical parameters have been variably decided at each labostory of Keio University affiliated hospitals. This may lead to inappropriate evaluation of these laboratory data for clinical decision making. We have, therefore, attempted to establish standard reference ranges of blood samples at 21 Keio University affiliated hospitals. Blood samples were collected from 192 healthy persons, who were selected according to the criteria of the National Committee for Clinical Laboratory Standards (NCCLS). The samples were subjected to common hematoloslcal tests performed mainly by automated methods. Statistical analyses were performed with non-parametric alternative method, and the standard reference ranges were expressed as mean士2SD. The results were as follows : free-T32.0-4.5pg/m1, free-T40.7-1.8 ng/dl, TSH 0.3-4.5 plU/ml, fasting plasma glucose 80-110mg/dl, HbA1C 4.0-5.5%, total cholestero1135-240 mg/dl, HDL-cholesterol 40-100 lng/d1, triglyceride 30-100 mg/dl, uric acid 3.0-7.0 mg/dl, creatinine 0.7-1.1mg/dl in men,0.4-0.8mg/dl in women, calcium 8.5-10.2 mg/dl, inoraganic phosphate 2.8-4.6 mg/dl. The majority of obtained standard reference ranges were closely related to Japanese standard values given in textbooks or previous reports of academic guidelines. Thus, the reference ranges reported here might be useful for accurate clinical assessment of endocrine, lipid and chemical data in Keio University affiliated hospitals.

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