| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_24592410seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:1.7 MB
|
| Last updated |
:Apr 11, 2016 |
| Downloads |
: 886 |
Total downloads since Apr 11, 2016 : 886
|
|
| Release Date |
|
| Title |
| Title |
進行性透析腎癌のmTOR阻害薬抵抗性の克服に向けた基礎研究
|
| Kana |
シンコウセイ トウセキ ジンガン ノ mTOR ソガイヤク テイコウセイ ノ コクフク ニ ムケタ キソ ケンキュウ
|
| Romanization |
Shinkosei toseki jingan no mTOR sogaiyaku teikosei no kokufuku ni muketa kiso kenkyu
|
|
| Other Title |
| Title |
Resistance to mTOR inhibitor in metastatic dialysis-related renal cell carcinoma
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
水野, 隆一
|
| Kana |
ミズノ, リュウイチ
|
| Romanization |
Mizuno, Ryuichi
|
| Affiliation |
慶應義塾大学・医学部・講師
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 60383824
|
| Name |
大家, 基嗣
 |
| Kana |
オオヤ, モトツグ
|
| Romanization |
Oya, Mototsugu
|
| Affiliation |
慶應義塾大学・医学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 00213885
|
| Name |
浅沼, 宏
|
| Kana |
アサヌマ, ヒロシ
|
| Romanization |
Asanuma, Hiroshi
|
| Affiliation |
慶應義塾大学・医学部・講師
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 70245570
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2015
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2014
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
本研究では, 通常腎癌に比較して透析腎癌では血管密度が低くmTORの活性化の頻度が高いことが明らかとなった。加えて透析腎の尿細管では恒常的にmTORの活性化が確認され, 透析腎癌の発生にはこの恒常的活性化が反映されている可能性が示唆された。さらにはチロシンキナーゼ阻害剤への暴露によってmTOR経路がさらに活性化することが明らかとなり, 治療抵抗性の一因となっている可能性が示唆された。
In dialysis-related renal cell carcinoma, mTOR was more strongly activated compared with conventional renal cell carcinoma. In addition, constitutive activation was also found in renal tubular cell in dialysis kidney, which would affect dialysis-related cancer initiation. Tyrosine kinase inhibitors accelerated mTOR activation in dialysis-related renal cell carcinoma.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24592410
研究分野 : 泌尿器癌全般
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
