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KAKEN_20K07184seika.pdf
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Download
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:4.3 MB
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| Last updated |
:Dec 11, 2024 |
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: 43 |
Total downloads since Dec 11, 2024 : 43
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老眼発症機序の解明とTRPVチャネルを標的とした抗老眼薬創製の基盤研究
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ロウガン ハッショウ キジョ ノ カイメイ ト TRPV チャネル オ ヒョウテキ トシタ コウロウガンヤク ソウセイ ノ キバン ケンキュウ
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Rōgan hasshō kijo no kaimei to TRPV chaneru o hyōteki toshita kōrōgan'yaku sōsei no kiban kenkyū
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Roles for the TRPVs channels in the lens in the initiation of presbyopia
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中澤, 洋介
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ナカザワ, ヨウスケ
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Nakazawa, Yosuke
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慶應義塾大学・薬学部 (芝共立) ・講師
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Research team head
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科研費研究者番号 : 60411708
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2023
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科学研究費補助金研究成果報告書
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2022
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本研究は、水晶体でのTRPVチャネルの機能解析と老視発症メカニズムについて検討を行った。これまでに水晶体のTRPVチャネルの局在を明らかにしており、本研究ではその局在に与える因子について検討を行った。その結果、外部温度や毛様体筋からの刺激圧変化によって局在が変化することを明らかにした。また、抗白内障候補化合物であるa-グルコシルヘスペリジンを自由飲水させるとマウス水晶体の弾性低下が抑制され、同時にTRPV4の局在が変化することを見出した。さらに、TRPV1のアゴニストを点眼するとある種の白内障発症が抑制されることを見出し報告した。
In this study, we examined the function of TRPV channels in the lens and contribution for presbyopia onset. We have previously reported the localization of TRPV channels in the lens, and examined the factors that influence their localization in this study. As a result, we found that the localization was changed by changes in external temperature and stimulation pressure from the ciliary muscle. We also found that administration of the anti-cataract candidate compounds hesperetin and water-soluble hesperidin suppressed the decrease in elasticity of the mouse lens due to altering the localization of TRPV channels. Furthermore, we found that Capsaicin, which is TRPV1 agonist, eye drops suppressed the development of secondary cataracts. In the future, we will examine TRPV channels in human lens samples and create the basis for the development of anti-presbyopia drugs.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2020～2022
課題番号 : 20K07184
研究分野 : 創薬化学
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