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KAKEN_19K09536seika.pdf
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:256.8 KB
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:Dec 23, 2024 |
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Total downloads since Dec 23, 2024 : 89
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難治性・浸潤性下垂体腺腫に関与する転写因子PITX2の機能解析
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| Kana |
ナンチセイ・シンジュンセイ カスイタイ センシュ ニ カンヨスル テンシャ インシ PITX2 ノ キノウ カイセキ
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Nanchisei shinjunsei kasuitai senshu ni kan'yosuru tensha inshi PITX2 no kinō kaiseki
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Functional analysis of PITX2 for refractory and invasive pituitary adenoma
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三輪, 点
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ミワ, トモル
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Miwa, Tomoru
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 20365282
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戸田, 正博
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トダ, マサヒロ
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Toda, Masahiro
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team member
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科研費研究者番号 : 20217508
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2022
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科学研究費補助金研究成果報告書
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2021
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下垂体腺腫の浸潤性を腫瘍の単純な増殖性とは異なる性質と考え、新たな因子を探索し、転写因子PITX2が浸潤性の下垂体腺腫で発現し、海面静脈洞への浸潤性と強く関与している可能性を得た。さらに、ホルモン非産生性のみならず、産生性（特に成長ホルモン、プロラクチン）下垂体腺腫においても、PITX2がその浸潤性と関係している可能性が示唆された。また上皮間葉系マーカーであるSNAIL1が腫瘍のサイズと相関を示す可能性も示唆された。一方で、下垂体腺腫細胞を低接着フラスコ上で長期培養する事は非常に難があった。一時的にSphere形成するが、passage後のgrowthが悪く長期的な培養は困難であった。
The cause of cavernous sinus (CS) invasion of pituitary neuroendocrine tumors (PitNETs) has not been fully elucidated. We analyzed the relationship between CS invasion in PitNETs and the expression of PITX2 and SNAIL1, which are the transcription factors associated with the morphogenesis of pituitary gland. We analyzed the expression of PITX2 and SNAIL1 employing quantitative real-time polymerase chain reaction and immunohistochemistry. PITX2 expression was significantly higher in PitNETs with CS invasion than PitNETs without CS invasion. Expression of SNAIL1 was significantly elevated in PitNETs with suprasellar expansion compared with PitNETs without suprasellar expansion. There was no apparent relationship between CS invasion and mitotic count, Ki-67 index, and p53 expression. High PITX2 expression was observed in non-functional PitNETs with CS invasion, suggesting that PITX2 may be involved in CS invasion of PitNETs.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2019～2021
課題番号 : 19K09536
研究分野 : 脳神経外科学
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| Dec 23, 2024 | | インデックス を変更 |
| Dec 23, 2024 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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