本研究はIn曝露作業者の腎/肝の慢性影響を検討した。参加者の平均年齢43歳、血清In濃度(In-S)5.0ng/ml(範囲<0.1-45.2)、KL-6 403U/ml(範囲143-1940)、参加者をIn-S別4群(低・中・高・超高濃度群:In-S<1, 1≦In-S<3, 3≦In-S<20, 20≦In-S)に分類した。
腎癌罹患はなく、In-SとALP(r=0.331)、In-SとシスタチンC(r=0.446)の間に弱い相関を認め、In-SとシスタチンCの所見率との間に量反応関係の傾向を認めたが、年齢調整後関連はなくなった。高/超高濃度群のn数が少ないため、さらなる検討が必要である。
In this study, we examined chronic effects on the kidneys and liver in indium (In)-exposed workers. The average age of the participants (n = 62) was 43 years, their In concentration in serum (In-S) was 5.0 ng/ml (range, <0.1-45.2), and their Krebs von den Lungen-6 (KL-6) was 403 U/ml (range, 143-1940). We divided the subjects into 4 groups according to In-S (Low, Medium, High and Very High groups: In-S<1, 1≦In-S<3, 3≦In-S<20, 20≦In-S, respectively) and compared among the 4 groups. Workers in the Low and Medium groups accounted for 79% of participants. There were no incidents of renal cancer, and there was a weak correlation between In-S and alkaline phosphatase (r=0.331) and Cystatin C (r=0.446). There was a dose-relationship between In-S and Cystatin C, however the relationship was no significant after adjusting for age. Further study is necessary to evaluate chronic effects on the kidneys and liver in the High and Very High In-S groups.

研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2018
課題番号 : 16K09107
研究分野 : 産業疫学