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KAKEN_15K10649seika.pdf
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Download
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:907.9 KB
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| Last updated |
:Nov 12, 2018 |
| Downloads |
: 370 |
Total downloads since Nov 12, 2018 : 370
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| Title |
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pDCを用いた末梢性免疫寛容誘導による移植臓器長期生着への戦略
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| Kana |
pDC オ モチイタ マッショウセイ メンエキ カンヨウ ユウドウ ニ ヨル イショク ゾウキ チョウキ セイチャク エノ センリャク
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pDC o mochiita masshōsei meneki kanyō yūdō ni yoru ishoku zōki chōki seichaku eno senryaku
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Prolongation of graft survival through peripheral tolerance mechanism via plasmacytoid dendritic cells
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篠田, 和伸
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シノダ, カズノブ
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Shinoda, Kazunobu
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| Affiliation |
慶應義塾大学・医学部(信濃町)・泌尿器科講師
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Research team head
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科研費研究者番号 : 60348737
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
マウス腎移植におけるspontaneous tolerance現象のメカニズムを解明しそれを臓器移植に応用することを目的とした。Spontaneous toleranceが成立する組み合わせgroup A(DBA→C57/BL6)と成立しない組み合わせgroup B(C3H→C57/BL6)でドナーpDCとレシピエントのナイーブT細胞の共培養をした。C57/BL6からのTreg誘導率はgroupAでは10-15%であったのに対しgroupBでは3-5%と有意な差が見られた。誘導されたTregを含む共培養細胞を1週間前に投与し心臓移植するとgroupAではgroupBよりも生着延長が得られた。
The aim of this study is to investigate the mechanism of spontaneous tolerance in mice kidney transplantation. We employed the tolerance combination (group A : DBA→C57/BL6) and non-tolerance combination (group B : C3H→C57/BL6) and cocultured donor type plasmacytoid DC and recipient type naive T cells. The induction rate of Tregs were significantly higher in group A (10-15%) than in group B (3-5%). Significant prolonged heart allograft survival was observed in group A by administering co-cultured cells containing induced Tregs a week before transplant.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K10649
研究分野 : 腎移植
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