Can all biological phenomena be explained only by fundamentalphysics? If this reductive project succeeds, biology can be eliminatedfrom the field of basic science. One standard way to accomplish thisproject consists of two stages: first, physico-chemistry explains all biologicalphenomena (1st-stage), then fundamental physics, especiallyquantum physics, explains physico-chemical phenomena (2nd-stage).In this model of reduction, molecular biology seems to play an essentialrole in the first stage. Is this model of reduction plausible? If molecularbiology needs non-physical setups for explanation, the answeris"no". Then, reduction fails, so biology is autonomous. In this paperI explore whether there are such setups in molecular biology. I'll arguethat there are such setups. In molecular biological explanation,such non-physical setups, knowledge concerning higher system（higher than molecular mechanism, like heart） and evolution, isneeded. At present, thus, there seems to be no realistic way to eliminatebiology.
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