This article is the investigation of the Early History of the Intercourse between Japan and Germany, that is between Japan and Prussian Empire, with special reference to the Prussia's expansion-mouvement into Far Eastern Asia, after the Opening of Japan in 1854. The History of Intercourse between these two countries can be divided into following three stages; (i) the period of the Opening of Japan, (1854～58), (ii) the period of the conclusion of Prusso- Japanese Treaty (1859～61), (iii) the period of the first sending of Japanese delegates to Prussia (1861～62). In this article, the following problems are fully discussed; (i) the conclusion of the Treaty of Peace and Amiety between Japan and U. S. A. and Prussia's Attitudes towards this Treaty; (ii) F. A. Luhdorf's efforts to establish the Treaty between Japan and Prussia; (iii) the conclusion of the Commercial Treaty between Japan and U. S. A. and Prsusia's reactions to this Treaty. This study is carried on mainly though the manuscripts kept in Preussische Geheimes Staatsarchiev, with subsidiary use of the Japanese documents.