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KAKEN_16K19953seika.pdf
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Download
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:176.8 KB
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:Apr 24, 2020 |
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Total downloads since Apr 24, 2020 : 472
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| Title |
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HSP27を標的に5-FU耐性を克服する新規薬剤の臨床化に向けた基礎研究
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| Kana |
HSP27 オ ヒョウテキ ニ 5-FU タイセイ オ コクフクスル シンキ ヤクザイ ノ リンショウカ ニ ムケタ キソ ケンキュウ
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HSP27 o hyōteki ni 5-FU taisei o kokufukusuru shinki yakuzai no rinshōka ni muketa kiso kenkyū
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Basic research of Heat Shock Protein 27 as a new target to overcome 5-fluorouracil resistance.
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浅田, 祐介
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アサダ, ユウスケ
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Asada, Yusuke
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慶應義塾大学・医学部(信濃町)・助教
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Research team head
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科研費研究者番号 : 50649952
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鶴田, 雅士
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ツルタ, マサシ
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Tsuruta, Masashi
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
ヒト大腸癌細胞株WiDr(親株)に5-fluorouracil(5-FU)を曝露することで, 耐性が出現した細胞株(耐性株)を樹立した。耐性株では, 親株と比較してHeat Shock Protein 27(HSP27)の発現が増強していた。耐性株において増強したHSP27を再抑制することで, 一旦出現した耐性の緩和を認めた。特に大腸癌化学療法中の耐性出現時における, HSP27を標的とした新たな治療の開発に向けた重要なデータである。
We generated the drug-resistant subclone of human colon cancer cell line WiDr by exposure to 5-fluorouracil (5-FU). Higher Heat Shock Protein 27 (HSP27) level was demonstrated in drug-resistant subclone than in naïve cell line. Down-regulation of overexpressed HSP27 suppressed generated 5-FU resistance in drug-resistant subclone. These data is important to develop a new therapy targeted on HSP27, especially to overcome generated resistance during chemotherapy in colon cancer.
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研究種目 : 若手研究(B)
研究期間 : 2016～2017
課題番号 : 16K19953
研究分野 : 外科学
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| History |
| Nov 12, 2018 | | インデックス を変更 |
| Jul 29, 2019 | | 版,出版地 場所,出版者 名前,出版者 カナ,日付 出版年(to:yyyy),著者版フラグ を変更 |
| Apr 24, 2020 | | Creator 著者ID を変更 |
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