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KAKEN_16K10609seika.pdf
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Title |
Title |
胆道癌・肝内胆管癌・膵癌におけるsynuclein gamma発現の意義
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Kana |
タンドウガン・カンナイ タンカンガン・スイガン ニ オケル synuclein gamma ハツゲン ノ イギ
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Romanization |
Tandōgan kannai tankangan suigan ni okeru synuclein gamma hatsugen no igi
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Gamma-Synuclein serves as a novel prognostic factor of extrahepatic and intrahepatic cholangiocarcinoma via promoting cell migration
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日比, 泰造
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ヒビ, タイゾウ
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Romanization |
Hibi, Taizō
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Affiliation |
慶應義塾大学・医学部 (信濃町)・共同研究員
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Research team head
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科研費研究者番号 : 10338072
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尾島, 英知
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Kana |
オジマ, ヒデノリ
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Romanization |
Ojima, Hidenori
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Collaborator
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竹村, 裕介
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Kana |
タケムラ, ユウスケ
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Romanization |
Takemura, Yūsuke
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Collaborator
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大島, 剛
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オオシマ, ゴウ
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Romanization |
Ōshima, Gō
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Collaborator
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北郷, 実
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Kana |
キタゴウ, ミノル
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Romanization |
Kitagō, Minoru
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阿部, 雄太
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アベ, ユウタ
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Romanization |
Abe, Yūta
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八木, 洋
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ヤギ, ヒロシ
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Romanization |
Yagi, Hiroshi
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Collaborator
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山岸, せり
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ヤマギシ, セリ
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Romanization |
Yamagishi, Seri
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堀, 周太郎
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ホリ, シュウタロウ
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Romanization |
Hori, Shūtaro
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久保田, 直人
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クボタ, ナオト
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Romanization |
Kubota, Naoto
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Collaborator
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坂元, 亨宇
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Kana |
サカモト, ミチイエ
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Romanization |
Sakamoto, Michiie
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北川, 雄光
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Kana |
キタガワ, ユウコウ
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Romanization |
Kitagawa, Yūkō
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Issued (from:yyyy) |
2019
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科学研究費補助金研究成果報告書
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2018
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Abstract |
2001年から2016年に慶應義塾大学病院にて根治的切除した肝内胆管癌(51例)、肝外胆管癌(98例)計149例のパラフィン切片から免疫染色によりSNCGの発現を調査し, SNCGの発現は32例(21%)に認めた。臨床病理学的因子との検討では神経浸潤とは有意な関連はなく、SNCG陽性群はSNCG陰性群よりも低分化と関連していた。それらは肝内胆管癌、肝外胆管癌においても同様の結果であった。SNCG陽性例は多変量解析にて予後不良因子として同定された。胆管癌細胞株17種類のうちSNCG発現をしていた3発現株を同定し、siRNAでノックダウンし、遊走能を調べたところsiRNAにより抑制された。
Methods: One hundred and forty nine cases of extra hepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC) were divided immunohistochemically into SNCG positive and negative groups. Clinicopathological factors and outcomes were compared between the groups. We selected BTC cell lines with SNCG overexpression from 17 BTC cell lines and examined the association between SNCG and cell proliferation or migration. Results: SNCG expression was observed in 32 (21.4%) cases and correlated with poorer differentiation (P=0.001) and lymph node metastases (P=0.001). Multivariate analyses revealed SNCG expression as an independent poor prognostic factor of overall survival (P=0.008 ) and recurrence-free survival (P=0.006). In vitro assays demonstrated SNCG silencing suppressed cell migration significantly and a part of cell proliferation.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2016~2018
課題番号 : 16K10609
研究分野 : 肝胆膵外科
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Oct 31, 2019 | | インデックス を変更 |
Oct 31, 2019 | | 著者 名前,著者 カナ,著者 ローマ字,著者 所属,著者 所属(翻訳),著者 役割,著者 外部リンク,著者 著者ID,抄録 内容,注記 を変更 |
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