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KAKEN_16K07065seika.pdf
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Download
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:112.1 KB
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:Oct 31, 2019 |
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Total downloads since Oct 31, 2019 : 146
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アストロサイトの構造機能連関とその制御の解明
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アストロサイト ノ コウゾウ キノウ レンカン ト ソノ セイギョ ノ カイメイ
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Asutorosaito no kōzō kinō renkan to sono seigyo no kaimei
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Characterization of structure function relatioship of astrocyte
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塗谷, 睦生
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ヌリヤ, ムツオ
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Nuriya, Mutsuo
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慶應義塾大学・医学部 (信濃町) ・准教授
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科研費研究者番号 : 60453544
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芦刈, 洋祐
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アシカリ, ヨウスケ
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Ashikari, Yōsuke
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水口, 高翔
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ミズグチ, タカハ
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Mizuguchi, Takaha
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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本研究では、近年脳の機能や疾患に重要な役割を果たすことが示唆されるようになってきた非神経グリア細胞であるアストロサイトの構造と機能の関係に関する研究を行った。ここから、アストロサイトの微細構造に存在する種々のタンパク質が、これまで神経細胞に作用することで効果を示すと考えられていた薬剤や生体分子によって非常に動的に制御されていることが明らかとなった。また、その機能を評価するのに有効となる顕微鏡法の開発と応用にも成功した。今後はこれらの成果を基に研究を進めて行くことで、健康・疾患状態の脳におけるアストロサイトの構造と機能、そしてその変化の役割の解明が進んで行くものと期待される。
In this study, we investigated the structure-function relationship of astrocytes, non-neuronal cells whose roles in brain physiology and pathophysiology have been recently realized. We revealed that various proteins that were located at the microstructures of astrocytes were dynamically regulated by drugs and biological molecules that had been considered to exert their functions through their actions on neurons. Furthermore, we have also succeeded in developing and applying microscopy methods that are effective in investigating astrocyte functions. Future studies based on these progresses are expected to reveal the structure function relationship of astrocytes and its roles in physiology and pathophysiology of the brain.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2018
課題番号 : 16K07065
研究分野 : 神経薬理学
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