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KAKEN_24590758seika.pdf
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:1.2 MB
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:Apr 11, 2016 |
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| Title |
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インジウム健診における肺拡散能検査の有効性の検討
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インジウム ケンシン ニ オケル ハイ カクサンノウ ケンサ ノ ユウコウセイ ノ ケントウ
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Injiumu kenshin ni okeru hai kakusanno kensa no yukosei no kento
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Validity assessment of DLco using portable equipment in health checks of indium-exposed workers.
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中野, 真規子
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ナカノ, マキコ
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Nakano, Makiko
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 70384906
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大前, 和幸
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オオマエ, カズユキ
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Omae, Kazuyuki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 60118924
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田中, 昭代
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タナカ, アキヨ
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Tanaka, Akiyo
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九州大学・医学研究院・講師
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Research team member
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科研費研究者番号 : 10136484
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平田, 美由紀
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ヒラタ, ミユキ
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Hirata, Miyuki
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九州大学・医学研究院・助教
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Research team member
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科研費研究者番号 : 30156674
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2015
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科学研究費補助金研究成果報告書
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2014
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本研究期間中にインジウム製造工場に勤務する作業者に健康調査を施行し, 影響の指標として肺拡散能(DLco)を測定した。測定値がQuality Grade A-Cの213名でDLco値の妥当性を検討後, 胸部CT所見の間質性変化, および気腫性変化スコアと比較した。相関係数(r)は, -0.320(気腫性変化とDLco), -0.412(気腫性変化と%DLco), -0.386(気腫性変化と%DLco/VA)とDLco, %DLco, %DLco/VAは間質性変化より気腫性変化のスコアとより相関が高かった。インジウム曝露者においてDLco値は, 胸部CT以外の気腫性変化の指標となる可能性が示唆された。
During the study period, we performed health checks on indium-exposed workers and measured diffuse lung capacity (DLco) as an effect marker of pulmonary function using a portable-type machine. After validity assessment of DLco with Quality Grade A-C (n=213), Spearman's correlation coefficient was conducted between DLCO and scores of emphysematous change or interstitial change on High-Resolution CT (HRCT) (n=48). Correlation coefficients (r) were -0.320 (emphysematous change and DLco), -0.412 (emphysematous change and %DLco) and -0.386 (emphysematous change and %DLco/VA). The correlation between emphysematous change on HRCT and %DLco was higher than that between interstitial change on HRCT and %DLco. Results suggested that DLco, %DLco and %DLco/VA in indium-exposed workers were effective markers for emphysema.
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研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24590758
研究分野 : 衛生学
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