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KAKEN_23390037seika.pdf
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Download
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:120.7 KB
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:Dec 11, 2014 |
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抗がん剤反応性のプロテオーム・メタボローム解析に基づく個別化投薬の新戦略
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| Kana |
コウガンザイ ハンノウセイ ノ プロテオーム・メタボローム カイセキ ニ モトズク コベツカ トウヤク ノ シンセンリャク
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Koganzai hannosei no puroteomu metaboromu kaiseki ni motozuku kobetsuka toyaku no shinsenryaku
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Proteomic and metabolomic analysis on chemo-sensitivity and resistance of cancer towards personalized medicine
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谷川原, 祐介
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タニガワラ, ユウスケ
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Tanigawara, Yusuke
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 30179832
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西, 弘二
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ニシ, コウジ
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Nishi, Koji
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慶應義塾大学・医学部・特任講師
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Research team member
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科研費研究者番号 : 00398249
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西牟田, 章戸
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ニシムタ, アキト
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Nishimuta, Akito
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慶應義塾大学・医学部・特任助教
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Research team member
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科研費研究者番号 : 00424135
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2014
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科学研究費補助金研究成果報告書
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2013
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抗がん剤の効果にみられる個人差はがん治療における大きな課題のひとつである。本研究は、タンパク質を介する応答を分析するプロテオーム解析と細胞内代謝を介する応答を分析するメタボローム解析という最新手法を用いて、癌に対する化学療法薬の作用機序と耐性メカニズムの解明を目的とした。薬理作用と耐性に関与する細胞内応答解析によって、抗がん剤反応性の個人差(有効または無効)を予測しうるバイオマーカー分子を複数見出し、個別化投薬へ展開するための基礎的知見を得た。
Inter-patient variability in the efficacy of cancer pharmacotherapy is one of the most difficult obstacles to improve cancer therapy. The present research investigated cellular mechanisms of pharmacological action of chemotherapeutic agents and resistant mechanisms of cancer against the drug action. The methods we used were the latest proteomic and metabolomic analyses which measured intracellular expression of abundant proteins and metabolites. Based on comprehensive metabolomic fingerprints and protein expression analysis, we have discovered several new proteins and metabolites that are related to the chemo-sensitivity or drug resistance of cancer. These findings are expected to lead to develop a new personalized cancer pharmacotherapy.
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研究種目 : 基盤研究(B)
研究期間 : 2011～2013
課題番号 : 23390037
研究分野 : 医歯薬学
科研費の分科・細目 : 薬学・医療系薬学
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