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KAKEN_18H04079seika.pdf
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Title |
Title |
メタボロミクスを用いたフレイル・認知機能低下に対する超早期リスク判別指標の開発
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Kana |
メタボロミクス オ モチイタ フレイル・ニンチ キノウ テイカ ニ タイスル チョウソウキ リスク ハンベツ シヒョウ ノ カイハツ
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Metaboromikusu o mochiita fureiru ninchi kinō teika ni taisuru chōsōki risuku hanbetsu shihyō no kaihatsu
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Development of risk prediction models for mild cognitive decline and frailty using metabolomics in a population-based cohort
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武林, 亨
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タケバヤシ, トオル
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Romanization |
Takebayashi, Toru
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Affiliation |
慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 30265780
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岡村, 智教
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Kana |
オカムラ, トモノリ
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Romanization |
Okamura, Tomonori
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Affiliation |
慶應義塾大学・医学部 (信濃町) ・教授
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Research team member
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科研費研究者番号 : 00324567
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寳澤, 篤
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ホウザワ, アツシ
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Romanization |
Hozawa, Atsushi
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Affiliation |
東北大学・東北メディカル・メガバンク機構・教授
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Research team member
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科研費研究者番号 : 00432302
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原田, 成
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Kana |
ハラダ, セイ
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Romanization |
Harada, Sei
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Affiliation |
慶應義塾大学・医学部 (信濃町) ・講師
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Research team member
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科研費研究者番号 : 10738090
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曽我, 朋義
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ソガ, トモヨシ
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Romanization |
Soga, Tomoyoshi
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Affiliation |
慶應義塾大学・政策・メディア研究科 (藤沢) ・教授
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Research team member
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科研費研究者番号 : 60338217
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仰木, 裕嗣
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Kana |
オオギ, ユウジ
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Romanization |
Ohgi, Yuji
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Affiliation |
慶應義塾大学・政策・メディア研究科 (藤沢) ・教授
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Research team member
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科研費研究者番号 : 90317313
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三浦, 克之
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Kana |
ミウラ, カツユキ
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Romanization |
Miura, Katsuyuki
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Affiliation |
滋賀医科大学・医学部・教授
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Research team member
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科研費研究者番号 : 90257452
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2023
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科学研究費補助金研究成果報告書
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2022
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Abstract |
フレイル・サルコペニア研究は65~80歳の2916名を対象に身体機能、歩行に関する評価を実施した。長時間睡眠はサルコペニアと正の関連があり、低筋力・低身体パフォーマンスと強い関連を示したが、睡眠の質の低さは通常の睡眠者でのみ関連していた。認知機能研究は、65~80歳の地域在住者855名の参加同意を得た。認知症専門医が最終判定した軽度認知機能低下は43名、MRI検査の所見は男性で無症候性脳梗塞、女性で深部皮質下白質病変の高度病変がもっと多く、海馬傍回、海馬、扁桃に若干の萎縮を認めたのは男女とも約1割であった。MCIのスクリーニングの感度はMoCA-Jが最も高く、特異度はAD8-Jが最も高かった。
In the Tsuruoka Metabolomics cohort study, frail/sarcopenia sub-study was conducted with 2,916 individuals aged 65 to 80 years. Long sleep duration showed a positive association with sarcopenia and a strong association with low muscle strength and low physical performance. However, poor sleep quality was only associated with normal sleepers. Cognitive sub-study recruited 855 community-dwelling individuals aged 65 to 80 years. Number with mild cognitive impairment, assessed determined by the dementia specialist, was 43. MRI examinations showed a higher prevalence of asymptomatic brain infarctions in males and deep subcortical white matter lesions in females. Mild atrophy was observed in the perirhinal cortex, hippocampus, and amygdala in approximately 10% of both males and females. The sensitivity for mild cognitive impairment was highest with the MoCA-J, while the AD8-J had the highest specificity as screening indices.
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研究種目 : 基盤研究 (A) (一般)
研究期間 : 2018~2022
課題番号 : 18H04079
研究分野 : 疫学
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Dec 11, 2024 | | インデックス を変更 |
Dec 11, 2024 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Creator 著者ID,Abstract 内容,Note 注記 を変更 |
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