フレイル・サルコペニア研究は65～80歳の2916名を対象に身体機能、歩行に関する評価を実施した。長時間睡眠はサルコペニアと正の関連があり、低筋力・低身体パフォーマンスと強い関連を示したが、睡眠の質の低さは通常の睡眠者でのみ関連していた。認知機能研究は、65～80歳の地域在住者855名の参加同意を得た。認知症専門医が最終判定した軽度認知機能低下は43名、MRI検査の所見は男性で無症候性脳梗塞、女性で深部皮質下白質病変の高度病変がもっと多く、海馬傍回、海馬、扁桃に若干の萎縮を認めたのは男女とも約1割であった。MCIのスクリーニングの感度はMoCA-Jが最も高く、特異度はAD8-Jが最も高かった。
In the Tsuruoka Metabolomics cohort study, frail/sarcopenia sub-study was conducted with 2,916 individuals aged 65 to 80 years. Long sleep duration showed a positive association with sarcopenia and a strong association with low muscle strength and low physical performance. However, poor sleep quality was only associated with normal sleepers. Cognitive sub-study recruited 855 community-dwelling individuals aged 65 to 80 years. Number with mild cognitive impairment, assessed determined by the dementia specialist, was 43. MRI examinations showed a higher prevalence of asymptomatic brain infarctions in males and deep subcortical white matter lesions in females. Mild atrophy was observed in the perirhinal cortex, hippocampus, and amygdala in approximately 10% of both males and females. The sensitivity for mild cognitive impairment was highest with the MoCA-J, while the AD8-J had the highest specificity as screening indices.

研究種目 : 基盤研究 (A) (一般)
研究期間 : 2018～2022
課題番号 : 18H04079
研究分野 : 疫学