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KAKEN_17K16982seika.pdf
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Download
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:259.1 KB
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| Last updated |
:Aug 23, 2023 |
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Total downloads since Aug 23, 2023 : 336
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| Title |
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AdipoR1シグナリングの網膜視細胞保護・失明予防の効果のメカニズム
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AdipoR1 シグナリング ノ モウマク シサイボウ ホゴ・シツメイ ヨボウ ノ コウカ ノ メカニズム
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AdipoR1 shigunaringu no mōmaku shisaibō hogo shitsumei yobō no kōka no mekanizumu
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The underlying mechanisms of protective role of AdipoR1 on retinal degeneration
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長田, 秀斗
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オサダ, ヒデト
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Osada, Hideto
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慶應義塾大学・医学部 (信濃町)・研究員
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Research team head
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科研費研究者番号 : 50748770
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小沢, 洋子
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オザワ, ヨウコ
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Ozawa, Yōko
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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アディポネクチン1型受容体 (Adiponectin receptor 1 ; AdipoR1) は全身で広く発現する内在性膜タンパク質で、脂肪細胞から分泌されるアディポネクチンにより活性化され、骨格筋などではグルコースおよび脂質の代謝を制御している。近年マウス、ヒトにおいてAdipoR1変異による網膜色素変性が報告されており、網膜におけるAdipoR1の重要性が示唆されている。しかし、網膜におけるAdipoR1機能の詳細は依然として不明な点が多い。そこで本研究ではAdipoR1欠損による網膜変性の解析を通じて網膜におけるAdipoR1の機能を明らかにした。
Adiponectin receptor 1 (AdipoR1) is expressed in various organs, including skeletal muscle, the liver, the spleen, and the retina. AdipoR1 is a well-known receptor of adiponectin, a major regulator of glucose and lipid homeostasis. Recent studies have reported that the mutation of AdipoR1 gene causes retinal degeneration, but its detailed mechanism remains unknown. Here we reported the detailed phenotype of retinal degeneration caused by AdipoR1 mutation. The mutation of AdipoR1 showed the retinal degeneration from very early stage of retinal development, and the severe retinal dysfunction. This indicates the important function of AdipoR1 in retinal development.
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研究種目 : 若手研究(B)
研究期間 : 2017～2018
課題番号 : 17K16982
研究分野 : 眼科学
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| Oct 31, 2019 | | インデックス を変更 |
| Aug 23, 2023 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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