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KAKEN_17K16943seika.pdf
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Download
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:77.6 KB
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| Last updated |
:Nov 15, 2022 |
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: 220 |
Total downloads since Nov 15, 2022 : 220
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| Title |
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ヒトiPS細胞より誘導した甲状腺細胞の甲状腺機能低下症への再生医療実現に向けて
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ヒト iPS サイボウ ヨリ ユウドウシタ コウジョウセン サイボウ ノ コウジョウセン キノウ テイカショウ エノ サイセイ イリョウ ジツゲン ニ ムケテ
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Hito iPS saibō yori yūdōshita kōjōsen saibō no kōjōsen kinō teikashō eno saisei iryō jitsugen ni mukete
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Regenerative medicine for hypothyroidism with thyroid follicular cells derived from human iPS cells
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伊藤, 文展
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イトウ, フミヒロ
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Itō, Fumihiro
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慶應義塾大学・医学部 (信濃町) ・共同研究員
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Research team head
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科研費研究者番号 : 40528329
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小川, 郁
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オガワ, カオル
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Ogawa, Kaoru
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Collaborator
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科研費研究者番号 : 00169179
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岡野, 栄之
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オカノ, ヒデユキ
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Okano, Hideyuki
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Collaborator
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科研費研究者番号 : 60160694
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小澤, 宏之
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オザワ, ヒロユキ
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Ozawa, Hiroyuki
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Collaborator
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科研費研究者番号 : 30327621
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藤岡, 正人
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フジオカ, マサト
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Fujioka, Masato
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Collaborator
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科研費研究者番号 : 70398626
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細谷, 誠
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ホソヤ, マコト
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Hosoya, Makoto
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Collaborator
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科研費研究者番号 : 30645445
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2020
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科学研究費補助金研究成果報告書
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2019
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| Abstract |
前研究課題から引き続き未完成であったヒトiPS細胞から甲状腺濾胞細胞の誘導方法の確立を目指した。既報の甲状腺前駆細胞誘導法や、甲状腺誘導方法を一部改編した条件で甲状腺前駆細胞のマーカーであるPAX8およびNKX2.1陽性 細胞を免疫染色にて確認することができた。しかしながらPCRにて十分なNKX2.1の発現が認められなかった。気道上皮誘導の既存報告も参考にし、条件変更を繰り返し行った。しかしながら同様にPCRではNKX2.1の発現量は多くはなかった。十分な誘導効率にて甲状腺前駆細胞を誘導する方法の確立ができず、甲状腺機能低下症への臨床応用はかなわなかった。
We tried that thyroid follicular cells were induced from human iPS cells. PAX8 and NKX2.1, they are markers of thyroid precursor cells, positive cells on immunostaining were derived from human iPS cells. However, no adequate expression of NKX2.1 was observed by PCR. Although the condition change was repeated, the same results were obtained. Currently, the method for inducing thyroid precursor cells with sufficient induction efficiency has not been established. We could not perform regenerative medicine for hypothyroidism.
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研究種目 : 若手研究 (B)
研究期間 : 2017～2019
課題番号 : 17K16943
研究分野 : 甲状腺
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| Mar 5, 2021 | | インデックス を変更 |
| Nov 15, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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