慶應義塾大学学術情報リポジトリ(KOARA)KeiO Associated Repository of Academic resources

慶應義塾大学学術情報リポジトリ(KOARA)

Home  »»  Listing item  »»  Detail

Detail

Item Type Article
ID
KAKEN_16H06482seika  
Preview
Image
thumbnail  
Caption  
Full text
KAKEN_16H06482seika.pdf
Type :application/pdf Download
Size :760.9 KB
Last updated :Dec 23, 2024
Downloads : 80

Total downloads since Dec 23, 2024 : 80
 
Release Date
 
Title
Title 場との連携による脳細胞の動態制御機構  
Kana バ トノ レンケイ ニ ヨル ノウサイボウ ノ ドウタイ セイギョ キコウ  
Romanization Ba tono renkei ni yoru nōsaibō no dōtai seigyo kikō  
Other Title
Title Mechanisms that control brain cell dynamics through interplay between cells and microenvironment  
Kana  
Romanization  
Creator
Name 仲嶋, 一範  
Kana ナカジマ, カズノリ  
Romanization Nakajima, Kazunori  
Affiliation 慶應義塾大学・医学部 (信濃町) ・教授  
Affiliation (Translated)  
Role Research team head  
Link 科研費研究者番号 : 90280734
Edition
 
Place
 
Publisher
Name  
Kana  
Romanization  
Date
Issued (from:yyyy) 2022  
Issued (to:yyyy)  
Created (yyyy-mm-dd)  
Updated (yyyy-mm-dd)  
Captured (yyyy-mm-dd)  
Physical description
1 pdf  
Source Title
Name 科学研究費補助金研究成果報告書  
Name (Translated)  
Volume  
Issue  
Year 2021  
Month  
Start page  
End page  
ISSN
 
ISBN
 
DOI
URI
JaLCDOI
NII Article ID
 
Ichushi ID
 
Other ID
 
Doctoral dissertation
Dissertation Number  
Date of granted  
Degree name  
Degree grantor  
Abstract
本研究では、発生時計依存的に産生され、脳表面の辺縁帯直下へと移動してくる大脳皮質ニューロンが、細胞周囲の場との連携を通してその動きや分化運命が制御される機構を明らかにすることを目指した。その結果、辺縁帯から分泌される分子が複数の受容体を使い分けてニューロン移動の適切な停止や凝集を制御して層形成を実現することや、発生時計による制御に加えて移動後の場からのシグナルによって最終的な分化運命が調整される機構の一端が明らかになった。
In the developing cortex, different types of cells are generated from neural stem/progenitor cells depending on the "developmental clock", and move toward their final destinations. The aim of this study was to clarify how the neuronal migration and differentiation are regulated through interactions with the surrounding cellular environment. As the results, we found that the migrating neurons receive an extracellular signal in the marginal zone to achieve the layer formation through interacting with multiple receptors, one for the termination of migration and another for enabling cellular aggregation. We also found that the neuronal identity in the cerebral cortex is not completely determined just by when the cells are born but also by the cellular environment that they find themselves in. It is thus thought that the cortex is formed through interplay between the cellular clock and the microenvironment.
 
Table of contents

 
Keyword
神経科学  

発生・分化  

脳・神経  

大脳皮質  

ニューロン  
NDC
 
Note
研究種目 : 新学術領域研究 (研究領域提案型)
研究期間 : 2016~2020
課題番号 : 16H06482
研究分野 : 発生神経生物学
 
Language
日本語  

英語  
Type of resource
text  
Genre
Research Paper  
Text version
publisher  
Related DOI
Access conditions

 
Last modified date
Dec 23, 2024 15:20:26  
Creation date
Dec 23, 2024 15:20:26  
Registerd by
mediacenter
 
History
Dec 23, 2024    インデックス を変更
 
Index
/ Public / Grants-in-Aid for Scientific Research / Fiscal year 2021 / Japan Society for the Promotion of Science
 
Related to