3通りの薬物投与経路(鼓室内, 腹腔内, 皮下)及び濃度の異なるヒアルロン酸を用いた際の蝸牛ラセン神経節への薬剤到達を検討することで, 内耳薬物治療に最適な投与法の確立を目指した。鼓室内投与群はばらつきが大きく, 統計学的に有意な結果は得られなかった。一方, HA抱合ルシフェリン皮下投与群は, 生理食塩水を溶媒としたルシフェリン溶液の皮下投与群, 腹腔内投与群と比べ最高濃度到達時間, 半減期が統計学的に有意に延長し蝸牛ラセン神経節に対するHA皮下投与の持続効果が示された。ヒアルロン酸の特徴を行かした鼓室内投与法を確立できれば, 理想的かつ革新的な内耳治療戦略の新たな展開が期待されると考えられた。
We measured drug delivery to the cochlear spiral ganglion using three drug administration routes and hyaluronic acid with different concentrations, and examined the optimal administration method for the inner ear. In the tympanic administration group, the variation was large, and statistically significant results could not be obtained. On the other hand, the HA-conjugated luciferin subcutaneous administration group showed a sustained effect of HA subcutaneous administration on the cochlear spiral ganglion compared with the subcutaneous administration group or the intraperitoneally administered group of luciferin solution using physiological saline as a solvent. If we could establish a tympanic administration method that characterized the characteristics of hyaluronic acid, it would be expected that a new development of an ideal and innovative inner ear treatment strategy would be expected.
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