我々は糖尿病網膜症に対する有酸素運動の網膜神経保護効果を検討した。8週齢のレプチン受容体欠損(db/db)マウスおよびヘテロ(m/db)マウスをそれぞれ非運動群, 運動群に分け普通食で飼育した。トレッドミルによる運動負荷を8週間行い, 16週齢の時点での暗順応網膜電図および明順応網膜電図を測定した。その結果db/dbマウスの非運動群の網膜電図で, 視細胞機能を反映するa波および網膜内層機能を反映するb波, Op波がそれぞれm/dbマウスと比較し低下がみられたが, 運動群では有意に維持されており有酸素運動での神経保護効果が認められた。
We investigated the effect of exercise training on retinal function in type 2 diabetic mice. 8-week-old type 2 diabetic mice (db/db) and heterozygous controls (db/m) either underwent forced treadmill exercise training for 8 weeks. Visual function was analyzed by photopic and scotopic electroretinogram (ERG) at week 8, the end of the experimental protocol. The a-wave, b-wave, and OP amplitudes in scotopic ERG, and b-wave amplitudes in photopic ERG, which represents cone system function, were all reduced in the db/db sedentary groups compared with the db/m sedentary group at week 8. However, these changes in the db/db mice were attenuated by exercise. The db/m showed no difference in ERG responses with or without exercise. Exercise training for 8 weeks preserved retinal function in db/db mice, suggesting that exercise may be a potential therapeutic approach to protect visual function in diabetes.
|
