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KAKEN_26460066seika.pdf
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Download
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:124.9 KB
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:Aug 2, 2019 |
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Total downloads since Aug 2, 2019 : 571
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| Title |
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老化関連Ｔ細胞の機能解析
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| Kana |
ロウカ カンレン Tサイボウ ノ キノウ カイセキ
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Rōka kanren Tsaibō no kinō kaiseki
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Functional analysis of senescence-associated T cells (SA-T)
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井上, 浄
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イノウエ, ジョウ
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Inoue, Jo
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慶應義塾大学・政策・メディア研究科・特任准教授
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Research team head
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科研費研究者番号 : 00433714
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2018
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科学研究費補助金研究成果報告書
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2017
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当研究グループは加齢とともに増加する老化関連T細胞(SA-T)を発見・同定してきた。本研究では, 老齢マウス, 種々の疾患モデルマウスにおけるSA-Tの機能を解析した。老齢マウスにおいてSA-Tの増加および胚中心反応の増加を確認し, 一部の個体で自己抗体の上昇を認めた。同様に自己免疫疾患モデルマウスであるNZB/W-F1マウスでは, 野生型マウスと比較して非常に若い時期からのSA-Tの増加, 胚中心反応の増加と自己抗体産生を認めた。興味深いことに, B細胞を欠損するマウスの解析では, 老齢個体であるにも関わらずSA-Tがほとんど存在しないことが明らかとなった。
Our group has found and identified senescence-associated T cells (SA-T) which increase with age. In this study, the functions of SA-T in aged mice and various disease model mice were analyzed. Increase of SA-T and increase of germinal center reaction were confirmed in aged mice, and auto-antibody increased in some individuals. Similarly, NZB / W-F1 mouse, an autoimmune disease model mouse, showed an increase in SA-T, an increase in germinal center reaction and auto-antibody production from young age as compared with wild type mouse. Interestingly, analysis of mice lacking B cells revealed that there was almost no SA-T despite being an aged individual.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2014～2017
課題番号 : 26460066
研究分野 : 免疫学
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| Nov 12, 2018 | | インデックス を変更 |
| Aug 2, 2019 | | 著者,抄録 内容,資源タイプ を変更 |
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