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KAKEN_25861705seika.pdf
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Download
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:174.7 KB
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:Aug 1, 2019 |
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Total downloads since Aug 1, 2019 : 897
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| Title |
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versican代謝産物 : DPEAAE分子の毛周期・発生における機能解析
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versican タイシャ サンブツ : DPEAAE ブンシ ノ モウシュウキ・ハッセイ ニ オケル キノウ カイセキ
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versican taisha sanbutsu : DPEAAE bunshi no moshuki hassei ni okeru kino kaiseki
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The analysis of DPEAAE in hair cycles
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高田, 圭以子
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タカダ, ケイコ
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Takada, Keiko
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慶應義塾大学・形成外科・助教
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Research team head
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科研費研究者番号 : 80624460
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荒牧, 典子
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アラマキ, ノリコ
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Aramaki, Noriko
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慶應義塾大学・形成外科・講師
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Research team member
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科研費研究者番号 : 80365311
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2015
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科学研究費補助金研究成果報告書
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2014
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| Abstract |
Versicanの分解産物であるversikine(DPEAAE)は, 免疫染色においてanagen期の毛乳頭に発現を認め, catagen期には発現が見られなかった。また毛乳頭細胞でAdamts-1,4,5のmRNAの発現を認め, versikineを培養細胞に添加すると細胞増殖能が促進された。
これらの結果から, versikineが毛乳頭細胞の増殖促進作用を持ち, 毛周期に関与していることが示唆された。
Versikine was detected in anagen of dermal papilla, but not in catagen by immunohistochemistry. Adamts-1,4,5 were shown in dermal papilla cells by RT-PCR.
Versikine was produced in dermal papilla from cleavage of versican by ADAMTSs.
From our data, versikine has an effect to promote dermal papilla cells and play an important role in hair cycles.
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研究種目 : 若手研究(B)
研究期間 : 2013～2014
課題番号 : 25861705
研究分野 : 皮膚創傷治癒
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| Aug 1, 2019 | | 著者,著者版フラグ を変更 |
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