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KAKEN_25750386seika.pdf
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海洋シアノバクテリア由来新規マクロリド化合物の機能と応用
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カイヨウ シアノバクテリア ユライ シンキ マクロリド カゴウブツ ノ キノウ ト オウヨウ
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Kaiyo shianobakuteria yurai shinki makurorido kagobutsu no kino to oyo
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The functional analyses of new macrolides isolated from marine cyanobacteria
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大野, 修
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オオノ, オサム
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Ono, Osamu
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慶應義塾大学・理工学部・助教
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Research team head
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科研費研究者番号 : 20436992
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末永, 聖武
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スエナガ, キヨタケ
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Suenaga, Kiyotake
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Research team member
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科研費研究者番号 :
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2015
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科学研究費補助金研究成果報告書
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2014
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海洋シアノバクテリアLyngbya sp.からビセリングビアサイドの新規類縁体であるビセリングビオライドB, CとビセリングビアサイドE, Fを単離し構造を決定した。特に強力な細胞増殖阻害活性を示したビセリングビオライドB, Cについて詳細な解析を試み, それらの小胞体ストレス誘導剤としての特性を明らかにした。また, ビセリングビアサイド類と同じく海洋シアノバクテリアLyngbya sp.より単離した新規ペプチド, クラハインについても小胞体ストレス誘導活性を見出した。クラハインの蛍光基及びビオチン導入プローブを用いた解析から, 小胞体への局在と小胞体Ca2+ポンプが標的分子であることを示す結果が得られた。
New biselyngbyaside analogs, biselyngbyolides B and C and biselyngbyasides E and F, were isolated from the marine cyanobacterium Lyngbya sp. Their structures were determined by spectroscopic analyses. These compounds inhibited the growth of human cancer cells, and biselyngbyolides B and C showed stronger activity than other analogs. Based on the detailed analyses of their biological activities, biselyngbyolides B and C were revealed to show potent endoplasmic reticulum (ER) stress-inducing activity. A new lipopeptide, kurahyne, was isolated from a cyanobacterial assemblage of Lyngbya sp. Kurahyne also exhibited ER stress-inducing activity. By the analyses using fluorescent and biotin conjugates of kurahyne, it was likely that kurahyne localized in ER and bound to ER Ca2+ pump.
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研究種目 : 若手研究(B)
研究期間 : 2013～2014
課題番号 : 25750386
研究分野 : 生物分子科学
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