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KAKEN_25461890seika.pdf
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Title |
Title |
実質臓器の凍結治療において血流の温度変化に与える影響に関する研究
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Kana |
ジッシツ ゾウキ ノ トウケツ チリョウ ニ オイテ ケツリュウ ノ オンド ヘンカ ニ アタエル エイキョウ ニ カンスル ケンキュウ
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Jisshitsu zoki no toketsu chiryo ni oite ketsuryu no ondo henka ni ataeru eikyo ni kansuru kenkyu
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A research on thermal sink effect during cryoablation for solid organs
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中塚, 誠之
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Kana |
ナカツカ, セイシ
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Romanization |
Nakatsuka, Seishi
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Affiliation |
慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 50188984
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井上, 政則
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Kana |
イノウエ, マサノリ
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Romanization |
Inoue, Masanori
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 30338157
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小黒, 草太
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Kana |
オグロ, ソウタ
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Romanization |
Oguro, Sota
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 50383716
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塚田, 実郎
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Kana |
ツカダ, ジツロウ
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Romanization |
Tsukada, Jitsuro
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Affiliation |
慶應義塾大学・医学部・共同研究員
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Research team member
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科研費研究者番号 : 50573276
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屋代, 英樹
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ヤシロ, ヒデキ
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Romanization |
Yashiro, Hideki
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Affiliation |
慶應義塾大学・医学部・共同研究員
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Research team member
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科研費研究者番号 : 90327643
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伊東, 伸剛
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Kana |
イトウ, ノブタケ
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Romanization |
Ito, Nobutake
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 00445248
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須山, 陽介
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Kana |
スヤマ, ヨウスケ
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Romanization |
Suyama, Yosuke
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 00594607
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田村, 全
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Kana |
タムラ, マサシ
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Romanization |
Tamura, Masashi
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 50594602
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2016
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科学研究費補助金研究成果報告書
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2015
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Abstract |
thermal sink effectの定量化を目的として, 流体循環ポンプシステムを用いて模擬血管・血流の条件(血管径, 血流量, 近接距離)を変化させながら, ゲル中の凍結端子周囲に作成されるアイスボールのサイズ, 形状の変化をCT下に観察した。その結果, 模擬thermal sink effectは模擬血管径, 血流量に相関して拡大し, 模擬血管・凍結端子間の距離に逆相関することが確認された。同時に, アイスボール断面積の拡大抑制(thermal sink effect)が変化しなくなる血流量の上限があることも示された。さらに豚肝実験でもthermal sink effectを観察する手法が確立できた。
In order to quantify the thermal sink effect, the shape, the size and the volume of ice balls in gel created around a cryoprobe were successfully visualized and measured under computed tomography, while varying the factors (the diameter, the flow rate and the distance from the cryoprobe) of a simulated vascular flow generated by a custom-made fluid-circulating pump system. According to our results, the simulated thermal sink effect had a good correlation with the diameter and the flow rate of the simulated vessel, while there was an opposite correlation between the thermal sink effect and the distance from the cryoprobe. In addition, it was revealed that there was an upper limit of the thermal sink effect with regard to the flow rate of the simulated vessel. In a swine liver, the thermal sink effect was successfully visualized by this fluid-circulating pump system to utilize for a future experiment.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013~2015
課題番号 : 25461890
研究分野 : 医歯薬学
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Aug 2, 2019 | | 著者 を変更 |
May 8, 2020 | | Creator を変更 |
Aug 23, 2023 | | Creator を変更 |
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