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KAKEN_25461521seika.pdf
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Download
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:197.9 KB
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:Jan 6, 2017 |
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| Title |
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服薬コンプライアンス評価法としての毛髪薬物濃度測定法の開発
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| Kana |
フクヤク コンプライアンス ヒョウカホウ トシテ ノ モウハツ ヤクブツ ノウド ソクテイホウ ノ カイハツ
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Fukuyaku konpuraiansu hyokaho toshite no mohatsu yakubutsu nodo sokuteiho no kaihatsu
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The development of the measuring assay for anti- HIV drug concentration of hair as the evaluation method of medication compliance
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岩田, 敏
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イワタ, サトシ
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Iwata, Satoshi
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 10129348
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長谷川, 直樹
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| Kana |
ハセガワ, ナオキ
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Hasegawa, Naoki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 20198724
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加藤, 真吾
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カトウ, シンゴ
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Kato, Shingo
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慶應義塾大学・医学部・専任講師
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Research team member
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科研費研究者番号 : 10177446
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藤原, 宏
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フジワラ, ヒロシ
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Fujiwara, Hiroshi
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慶應義塾大学・医学部・助教
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Research team member
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須藤, 弘二
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スドウ, コウジ
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Sudo, Koji
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慶應義塾大学・医学部・特任助教
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Research team member
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科研費研究者番号 : 30566899
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
血中抗HIV薬濃度の測定は, 治療効果の最適化と薬剤耐性獲得の防止のために重要である。一方, 毛髪中の薬剤量は平均的な薬剤血中濃度を反映していると考えられており, 毛根側から先端にかけての毛髪中薬剤量を測定することにより血中濃度の長期的推移を推定できることが期待される。今回我々はビーズ破砕による毛髪からの薬剤抽出法を確立し, 逆転写酵素阻害剤であるテノフォビル(TFV)とエムトリシタビン(FTC)服用中の患者の毛髪および血漿中の薬剤量を, LC-MS/MSを用いて測定した。その結果, 毛髪中薬剤量を測定することにより, TFVとFTCの血中濃度の長期的推移を推定できる可能性が示された。
Measuring blood concentration of anti- HIV drugs is important for the optimization of the treatment and the prevention of the acquisition of drug-resistance. The drug concentration in hair is thought to reflect average blood concentration of the drug, and it is expected that we can estimate the long-term change of the blood levels of the drug by measuring drug concentrations of hairs from hair roots to hair tips. This time we established the beads spall method for the drug extraction from the hair, and we measured the hair and blood concentrations of tenofovir (TFV) and emtricitabine (FTC), which are reverse transcriptase inhibitors, in HIV infected patients by using a liquid chromatography mass spectrometry. As a result, the possibilities to be able to estimate the long-term change of the blood levels of TFV and FTC by measuring the drug concentration of the hair were shown.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25461521
研究分野 : 感染症学
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