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KAKEN_24790591seika.pdf
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インジウム等重金属曝露作業者における酸化ストレスマーカーとの量影響関係
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インジウムトウ ジュウキンゾク バクロ サギョウシャ ニ オケル サンカ ストレス マーカー トノ リョウ エイキョウ カンケイ
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Injiumuto jukinzoku bakuro sagyosha ni okeru sanka sutoresu maka tono ryo eikyo kankei
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Dose-effect relationship between heavy-metal exposure levels and oxidative stress markers in heavy-metal exposed workers
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岩澤, 聡子
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イワサワ, サトコ
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Iwasawa, Satoko
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 10570369
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大前, 和幸
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オオマエ, カズユキ
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Omae, Kazuyuki
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 60118924
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中野, 真規子
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ナカノ, マキコ
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Nakano, Makiko
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 70384906
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2014
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科学研究費補助金研究成果報告書
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2013
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本研究の目的は、重金属曝露作業者における酸化ストレスマーカーとの量影響関係を検討することである。対象は、二次鉛精錬工場における男性作業者27名と、金属インジウムおよびインジウム化合物作業者59名であった。曝露指標として、血中鉛(Pb-B)と血清インジウム(In-S)濃度を用いた。影響指標としては、リン脂質で過酸化を受け合成する8-iso-PGF、およびDNAの酸化損傷指標8-OHdGを、生体内の酸化ストレスマーカーとして用いた。鉛曝露作業者において曝露と尿中8-iso-PGFおよび尿中8-OHdGとの量影響関係を明らかにすることができたが、インジウム曝露との間では関連が示されなかった。
The aim of this study was to investigate the dose-effect relationships between heavy metal exposure and oxidative stress markers. The subjects were 27 male workers in a lead secondary smelting factory, and 59 workers exposed to indium metal or indium compounds. Lead in whole blood (Pb-B) or indium in serum (In-S) was measured as an exposure index of lead or indium. Urinary 8-hydroxydeoxyguanosine (8-OHdG) and urinary 8-isoprostaglandin F2 alpha(8-iso-PGF) were determined as a DNA peroxidation stress marker and as a cell membrane peroxidation stress biomarker. Significant exposure-effect relationships were observed between Pb-B and 8-OHdG, and between Pb-B and 8-iso-PGF. Lead exposure may induce peroxidation stress on DNA and cell membrane lipid. Conversely, there were no significant relationships between In-S and two biomarkers.
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研究種目 : 若手研究(B)
研究期間 : 2012～2013
課題番号 : 24790591
研究分野 : 医歯薬学
科研費の分科・細目 : 社会医学・衛生学
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