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KAKEN_19K20698seika.pdf
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骨疾患治療のための骨環境応答性ナノツールの開発
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コツ シッカン チリョウ ノ タメ ノ コツ カンキョウ オウトウセイ ナノツール ノ カイハツ
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Kotsu shikkan chiryō no tame no kotsu kankyō ōtōsei nanotsūru no kaihatsu
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Development of bone-responsive drug delivery system for the therapy of osteoporosis
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福井, 有香
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フクイ, ユウカ
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Fukui, Yūka
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慶應義塾大学・理工学部 (矢上) ・講師
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Research team head
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科研費研究者番号 : 50635836
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2021
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科学研究費補助金研究成果報告書
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2020
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骨粗鬆症は、加齢とともに破骨細胞による骨吸収と骨芽細胞による骨形成のバランス(リモデリング)が崩れて、骨密度と骨質の低下が誘発される疾患である。そこで、本研究では、生体膜由来のカプセル素材であるリポソームをプラットフォームとして、骨環境に応答して、骨吸収と骨形成の同時コントロールを可能にするカプセル(骨環境応答性ナノツール)の開発に取り組んだ。(1)破骨細胞周辺の酸性環境に応答して、表面が骨結合性から細胞内移行性へと変化し、薬剤を放出するカプセルの作製に成功した。また、(2)骨形成素材であるリン酸カルシウム結晶を複合化したカプセルの作製を達成した。
In recent years, the number of people who suffer from osteoporosis are increasing with the shift to an aging society and change in people’s lifestyles. In this study, we developed therapeutic materials for osteoporosis. First, we produced a nanocapsule via deposition of biopolymers on the surface of liposome. The polymer wall was constructed with an inner layer with cell penetration activity and an outer layer with bone-targeting ability. The enzymatic degradation of the outer layer in response to the acidic environment provided by osteoclasts led to the surface display of inner layer. In addition, enzymatic degradation of the polymer wall facilitated the release of cargo. Therefore, it is expected that the nanocapsule will deliver drugs to osteoclasts to reduce bone resorption. Next, calcium phosphate, which is the main constituent of bone, was produced inside the liposome. We expect that delivery of nanosized calcium phosphate to bone tissue will promote the bone formation.
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研究種目 : 若手研究
研究期間 : 2019~2020
課題番号 : 19K20698
研究分野 : 高分子化学
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