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KAKEN_18K15602seika.pdf
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Download
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:363.4 KB
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| Last updated |
:Mar 5, 2021 |
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Total downloads since Mar 5, 2021 : 215
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| Title |
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膠芽腫の低酸素領域克服に向けた薬剤の同定と解析
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コウガシュ ノ テイサンソ リョウイキ コクフク ニ ムケタ ヤクザイ ノ ドウ テイ ト カイセキ
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Kōgashu no teisanso ryōiki kokufuku ni muketa yakuzai no dō tei to kaiseki
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Identification and analysis of drugs for overcoming hypoxia in glioblastoma
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小池, 直義
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コイケ, ナオヨシ
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Koike, Naoyoshi
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 60464913
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2020
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科学研究費補助金研究成果報告書
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2019
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膠芽腫の放射線抵抗性は腫瘍内低酸素領域が原因であることに着目し、低酸素領域特異的に集積するニトロイミダゾール化合物に着目した。ドラニダゾールは、膠芽腫の低酸素領域の放射線増感作用に加え、単独で低酸素領域にある腫瘍に対し殺細胞効果があることを明らかにし、その作用機序としてミトコンドリアへの影響を見出した。同種同所移植マウスモデルにおいてドラニダゾールと放射線照射の併用はマウスの生存延長に寄与し、ドラニダゾールが膠芽腫の放射線増感剤として有望な薬剤であることが示唆された。
The radioresistance of glioblastoma is caused by the hypoxic region in the tumor. The nitroimidazole compounds that accumulates specifically in the hypoxic region were analyzed for overcoming radioresistance. Among nitroimidazole compounds, doranidazole had a radiosensitizing effect in the hypoxic region of glioblastoma and a cell-killing effect by itself. The mechanism of cell death by doranidazole was mitochorial stress. In the allogeneic orthotopic mouse brain tumor model, the combined use of doranidazole and irradiation contributed to prolongation of mouse survival.
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研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K15602
研究分野 : 放射線腫瘍学
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