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KAKEN_18K06137seika.pdf
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| Title |
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新たなC型糖修飾責任酵素の同定と基質タンパク質の解析
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アラタナ Cガタ トウ シュウショク セキニン コウソ ノ ドウテイ ト キシツ タンパクシツ ノ カイセキ
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Aratana Cgata tō shūshoku sekinin kōso no dōtei to kishitsu tanpakushitsu no kaiseki
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Identification of novel enzymes for C-mannosylation and analysis of its substrate proteins
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清水, 史郎
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シミズ, シロウ
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Simizu, Sirō
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慶應義塾大学・理工学部 (矢上) ・教授
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Research team head
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科研費研究者番号 : 30312268
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2021
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科学研究費補助金研究成果報告書
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2020
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本研究課題はC型糖修飾の責任酵素の同定と新たな基質探索を目指したものである。期間中に、責任酵素同定のため、C型糖修飾を簡便に検出する方法を開発することができた。さらに、R-spondin2、MFAP4、ADAMTS4そしてIsthmin-1を新たなC型糖修飾の基質タンパク質として同定することができた。それぞれの基質タンパク質は機能解析も行い、C型糖修飾が種々のタンパク質において重要な役割を担っていることが示された。
The objective of the research is to identify the enzyme responsible for C-mannosylation and to search for new substrate proteins. During the period, we were able to develop a simple method for detecting C-mannosylation to identify the responsible enzyme(s). Furthermore, we identified R-spondin2, MFAP4, ADAMTS4 and Isthmin-1 as novel C-mannosylated proteins. Functional analysis of each substrate protein was also performed, and it was demonstrated that C-mannosylation plays an important role in various protein functions.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K06137
研究分野 : 糖質科学
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