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KAKEN_17H05082seika.pdf
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:736.0 KB
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| Last updated |
:May 17, 2022 |
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Total downloads since May 17, 2022 : 374
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| Title |
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炎症抑制能をもつ新規腸管上皮内細胞の遺伝子制御の解明
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| Kana |
エンショウ ヨクセイノウ オ モツ シンキ チョウカン ジョウヒナイ サイボウ ノ イデンシ セイギョ ノ カイメイ
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Enshō yokuseinō o motsu shinki chōkan jōhinai saibō no idenshi seigyo no kaimei
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Elucidation of the genetic regulation of novel intestinal intraepithelial lymphocytes with anti-inflammatory properties
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筋野, 智久
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スジノ, トモヒサ
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Sujino, Tomohisa
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 40464862
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2021
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科学研究費補助金研究成果報告書
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2020
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腸管上皮における免疫細胞においては特にCD4CD8aaT細胞という抑制系のT細胞が存在することが明らかになった。さらにTregから一部分化することをこれまでに示したが、その細胞分化に重要な因子については不明であった。CD4CD8aa細胞における分化に必要な特徴的な遺伝子と同定し、関連性を証明した。さらにヒト炎症性腸疾患患者においても同じ遺伝子群がCD4CD8aaT細胞に関与していることを示した。
We found that immune cells in the intestinal epithelium contain suppressor T cells, CD4CD8aaT cells in particular. We have also shown that CD4CD8aa T cells differentiate in part from Treg cells, but the factors that are important for their differentiation are unknown. We identified the key genes to develop CD4CD8aa T cells in intraepithelial compartment. In addition, we showed that the same gene is involved in CD4CD8aaT cells in human patients with inflammatory bowel disease.
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研究種目 : 若手研究 (A)
研究期間 : 2017～2019
課題番号 : 17H05082
研究分野 : 炎症性腸疾患
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