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KAKEN_16K20329seika.pdf
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Download
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:177.6 KB
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:Aug 29, 2019 |
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| Title |
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光ストレスによる網膜のミトコンドリア障害と細胞死
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| Kana |
ヒカリ ストレス ニ ヨル モウマク ノ ミトコンドリア ショウガイ ト サイボウシ
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Hikari sutoresu ni yoru mōmaku no mitokondoria shōgai to saibōshi
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Light-induced mitochondria damage and cell death in the retina
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戸田, 枝里子
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トダ, エリコ
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Toda, Eriko
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| Affiliation |
慶應義塾大学・医学部(信濃町)・研究員
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Research team head
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科研費研究者番号 : 90722992
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小澤, 洋子
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オザワ, ヨウコ
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Ozawa, Yōko
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Research team member
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川島, 弘彦
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カワシマ, ヒロヒコ
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Kawashima, Hirohiko
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
暗順応後の6週齢のBalb/c雄マウスに対し光照射を行い, 誘導される細胞死をTUNELアッセイにより解析したところ, 2日後に視細胞でのみアポトーシスが亢進していた。TUNEL陽性反応はDapiで示される核にあったため, 染色性の妥当性を確認することができた。ミトコンドリアに作用する抗酸化剤を投与し, 同様の光照射を行い, アポトーシスについて解析した。現時点までには, アポトーシス細胞に対する明らかな影響は示されていない。
Six-week old Balb/c male mice were exposed to the light after dark adaptation, and the cell death in the retina was analyzed using TUNEL assay. The TUNEL positive and apoptotic cells were increased only in the photoreceptor layer 2 days after light exposure. The TUNEL staining was positive in the nuclei which were defined by the staining with Dapi. The mice were treated with an antioxidant, which is supposed to affect mitochondria, before light exposure to analyze the effects on the apoptosis, although the significant effect was not detected.
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研究種目 : 若手研究(B)
研究期間 : 2016～2017
課題番号 : 16K20329
研究分野 : 眼科学
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| Nov 12, 2018 | | インデックス を変更 |
| Aug 29, 2019 | | 出版地 場所,出版者 名前,出版者 カナ,出版者 ローマ字,日付 出版年(from:yyyy),日付 出版年(to:yyyy),日付 作成日(yyyy-mm-dd),日付 記録日(yyyy-mm-dd),形態,上位タイトル 名前,上位タイトル 号 を変更 |
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