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KAKEN_16K15292seika.pdf
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Download
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:366.6 KB
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:Oct 31, 2019 |
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Total downloads since Oct 31, 2019 : 2065
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Stem Cell Memory T細胞の創出と応用
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Stem Cell Memory T サイボウ ノ ソウシュツ ト オウヨウ
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Stem Cell Memory T saibō no sōshutsu to ōyō
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Generation and application of Stem Cell Memory T Cells
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吉村, 昭彦
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ヨシムラ, アキヒコ
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Yoshimura, Akihiko
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慶應義塾大学・医学部 (信濃町)・教授
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Research team head
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科研費研究者番号 : 90182815
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近藤, 泰介
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コンドウ, タイスケ
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Kondō, Taisuke
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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最近、新規メモリーT細胞サブセットである幹細胞メモリーT (Tscm) 細胞が発見され、新たなT細胞移入療法の素材として注目されている。Tscm細胞は長命で抗原刺激に応答して急速に増殖し、多数のエフェクターT細胞を産生する。我々はヒト末梢血よりEBウイルスや腫瘍抗原特異的T細胞を増幅させたのち、ヒトNotch-ligand, hDLL1を発現するOP9細胞と共培養することにより、エフェクターT細胞をTscm様細胞 (iTscm) に転換できることを示した。iTscm細胞はヒト化マウスモデルにおいて従来の活性化T細胞よりもはるかに強い抗腫瘍能力を示した。
A novel memory T cell subset, stem cell memory T (Tscm) cell, was recently discovered and is believed to be a useful tool for new T cell transfer therapy. Since Tscm cells are long-lived, and proliferate rapidly in response to antigenic stimulation to produce large numbers of effector T cells. We amplified EB virus and tumor antigen-specific T cells from human peripheral blood and co-cultured with human Notch-ligand and OP9 cells expressing hDLL1. This procedure converted effector T cells into Tscm-like cells (iTscm). We showed that iTscm cells have shown much more potent anti-tumor activity than conventional activated T cells in a humanized mouse model.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2016～2018
課題番号 : 16K15292
研究分野 : 免疫学
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