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KAKEN_15K21370seika.pdf
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ニコチン受容体修飾因子SLURP-1による乾癬の新規治療戦略
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ニコチン ジュヨウタイ シュウショク インシ SLURP-1 ニ ヨル カンセン ノ シンキ チリョウ センリャク
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Nikochin juyotai shushoku inshi SLURP-1 ni yoru kansen no shinki chiryo senryaku
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A novel therapeutic strategy against psoriasis by using nicotinic acetylcholine receptor modulator, SLURP-1
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森脇, 康博
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モリワキ, ヤスヒロ
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Moriwaki, Yasuhiro
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慶應義塾大学・薬学部・専任講師
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Research team head
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科研費研究者番号 : 00392150
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辻, 祥太郎
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ツジ, ショウタロウ
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Tsuji, Shotaro
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Research team member
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2017
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科学研究費補助金研究成果報告書
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2016
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遺伝性掌蹠角化症の一種であるMal de Meleda病(MDM病)の原因遺伝子としてSLURP-1が同定されている。最近, SLURP-1欠損マウスがMDM病と同様の病態を引き起こすことが確認され, SLURP-1が皮膚の恒常性を維持する上で必要不可欠な分子であることが示された。一方で, SLURP-1の乾癬などのMDM病以外の皮膚疾患との関連については未だ明らかにされていなかった。我々は, 乾癬モデルマウスを用いてSLURP-1が乾癬の病態形成に関与していることを明らかにした。また, SLURP-1が乾癬の病態増悪因子である黄色ブドウ球菌に対して抗菌活性を有することを見出した。
SLURP1 is the causal gene for Mal de Meleda (MDM), an autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis. Recently, SLURP1-deficient mice show MDM-like symptoms such as severe palmoplantar keratoderma characterized by increased keratinocyte proliferation and water barrier defects. Although SLURP1 likely serves as an important proliferation/differentiation factor in keratinocytes, the possible relation between SLURP1 and other skin diseases, such as psoriasis and atopic dermatitis, has not been studied. In our experiment, we found SLURP1 expression is greatly increased within the skin lesions in a psoriatic mouse model. In addition, recombinant SLURP1 suppressed the growth of S. aureus, which is associated with disease severity in psoriasis. These results suggest that SLURP1 may contribute to the pathogenesis of psoriasis.
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研究種目 : 若手研究(B)
研究期間 : 2015~2016
課題番号 : 15K21370
研究分野 : 神経免疫
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