| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_15K19135seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:285.7 KB
|
| Last updated |
:Jul 29, 2019 |
| Downloads |
: 866 |
Total downloads since Jul 29, 2019 : 866
|
|
| Release Date |
|
| Title |
| Title |
制御性T細胞のエピジェネティック制御機構の解明と免疫疾患への応用
|
| Kana |
セイギョセイ Tサイボウ ノ エピジェネティック セイギョ キコウ ノ カイメイ ト メンエキ シッカン エノ オウヨウ
|
| Romanization |
Seigyosei Tsaibo no epijenetikku seigyo kiko no kaimei to meneki shikkan eno oyo
|
|
| Other Title |
| Title |
The role of TET proteins in stability and function of regulatory T cells.
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
中司, 寛子
|
| Kana |
ナカツカサ, ヒロコ
|
| Romanization |
Nakatsukasa, Hiroko
|
| Affiliation |
慶應義塾大学・医学部・日本学術振興会特別研究員(PD)
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 90749334
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2017
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2016
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
制御性T細胞(Treg)は免疫寛容に重要なT細胞であり, その安定性はマスター遺伝子であるFoxp3のDNA脱メチル化が関与すると報告されたが, 未だその制御機構には不明な点が多い。本研究では, DNA脱メチル化酵素であるTet2/3がT細胞およびTregにおいてDNA脱メチル化を制御することでその分化や安定性, 機能に重要な役割を担うことを明らかとした。さらに, 人工的にFoxp3遺伝子の部位特異的DNA脱メチル化を誘導することに成功した。
Regulatory T cells (Tregs) play a pivotal role in regulating immune responses and maintaining immunological tolerance. Although DNA demethylation has been proposed to be essential for the stable expression of Foxp3, a master regulator of Treg, actual contribution of DNA demethylating enzymes (Tet family proteins) in Treg stability and function remain to be elucidated. In this study, we analyzed T cell- or Treg-specific Tet2/3-deficient mice and found that Tet2/3 play important roles in the differentiation, stability and function of T cells and Tregs through regulating DNA demethylation. Furthermore, we have successfully induced region-specific demethylation in Foxp3 gene locus.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究(B)
研究期間 : 2015～2016
課題番号 : 15K19135
研究分野 : 免疫学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
| Jul 29, 2019 | | 著者,抄録 内容,ジャンル を変更 |
|
|
| Index |
|
| Related to |
|
