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KAKEN_15K18933seika.pdf
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Download
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:167.2 KB
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:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 601
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| Title |
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リウマチ性疾患へのアザチオプリンの治療効果に対する遺伝子型の影響とその機序の解明
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リウマチセイ シッカン エノ アザチオプリン ノ チリョウ コウカ ニ タイスル イデンシガタ ノ エイキョウ ト ソノ キジョ ノ カイメイ
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Riumachisei shikkan eno azachiopurin no chiryō kōka ni taisuru idenshigata no eikyō to sono kijo no kaimei
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Effect of genetic polymorphisms of azathioprine-metabolizing enzymes on response to rheumatoid arthritis treatment
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青森, 達
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アオモリ, トオル
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Aomori, Toru
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慶應義塾大学・薬学部・准教授
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Research team head
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科研費研究者番号 : 40620802
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土屋, 亜由美
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ツチヤ, アユミ
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Tsuchiya, Ayumi
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坂本, 麻美
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サカモト, マミ
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Sakamoto, Mami
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竹内, 亜理沙
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タケウチ, アリサ
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Takeuchi, Arisa
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石岡, 江梨子
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イシオカ, エリコ
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Ishioka, Eriko
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金子, 裕子
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カネコ, ユウコ
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Kaneko, Yuko
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2018
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科学研究費補助金研究成果報告書
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2017
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| Abstract |
本研究では関節リウマチ患者を対象として, アザチオプリン(AZA)の代謝に関連する酵素の遺伝子多型と治療効果との関連を調査した。
AZA代謝酵素の一つであるイノシントリホスファターゼ(ITPA)に, 変異がある患者(変異群)とない患者(野生群)とで比較した結果, AZAの投与量は変異群で 0.851±0.302 mg/kg/day, 野生群で1.24±0.463mg/kg/dayであった。治療の反応性について6ヵ月間のDAS28の変化には両群で有意差はなかった。以上のことからITPA変異群のは野生群と比べて, より少ない投与量で同等の治療効果を得ていたことが明らかとなった。
The aim of this study was to evaluate the association between the genetic polymorphisms of azathioprine (AZA) -metabolizing enzymes and their influence on rheumatoid arthritis treatment.
As a result of comparison between patients with and without mutation in inosine triphosphatase (ITPA), one of the metabolic enzymes of AZA, the dosage of AZA was 0.851±0.302 mg/kg/day in the mutant group, while 1.24±0.463 mg/kg/day in the wild type group. On the other hand, there was no significant difference between the two groups in the change of DAS28 during 6 months, which is an index of the therapeutic effect. As a conclusion, patients with ITPA mutation had equivalent therapeutic effect with a lower dose compared with patients without the mutation.
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研究種目 : 若手研究(B)
研究期間 : 2015～2017
課題番号 : 15K18933
研究分野 : 臨床薬学
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