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KAKEN_23592413seika.pdf
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子宮腔内液性因子に注目した着床不全の病態解明と治療法の開発
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シキュウ クウナイ エキセイ インシ ニ チュウモク シタ チャクショウ フゼン ノ ビョウタイ カイメイ ト チリョウホウ ノ カイハツ
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Shikyu kunai ekisei inshi ni chumoku shita chakusho fuzen no byotai kaimei to chiryoho no kaihatsu
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Development of treatment and pathogenesis of implantation failure with a focus on the uterine cavity humoral factor
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井上, 治
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イノウエ, オサム
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Inoue, Osamu
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 10464976
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浜谷, 敏生
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ハマタニ, トシオ
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Hamatani Toshio
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 60265882
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宮戸, 健二
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ミヤド, ケンジ
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Miyado, Kenji
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独立行政法人国立成育医療研究センター・生殖・細胞医療研究部・室長
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Research team member
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科研費研究者番号 : 60324844
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2014
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科学研究費補助金研究成果報告書
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2013
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本研究では、子宮腔内のCD9に注目し、CD9の子宮内膜における役割を明らかにすることを目的とした。卵におけるCD9発現のみをレスキューしたトランスジェニックマウス(CD9-/-TG)では、分娩後の子宮内膜は上皮で覆われておらず、広範な癒着が認めた。子宮内腔液の液性因子を測定したところ、野生型マウスと比較しCD9-/-TGではVEGFが減少しており、CD9欠損はVEGF産生に障害を及ぼす可能性が考えられた。そこでCD9-/-TGの子宮腔にVEGFを投与すると、子宮内膜の再上皮化が観察され、CD9は子宮内膜上皮細胞からのVEGFの分泌に寄与し、子宮内膜修復過程に重要な役割を働いていると考えられた。
CD9 is a 24-kD membrane protein, which is localized on endosomes and exosomes as well as cell membranes. Cd9-deficient mouse eggs are unable to fuse with sperm. In this study, we intended that we focused on CD9 of the uterine cavity, and to clarify the role of CD9 in the endometrium. In transgenic mice that were rescued only CD9 expression in the zona pellucida (CD9-/-TG), endometrium of postpartum were not covered with the epithelium, were found extensive adhesions. After measurement of the humoral factors of the uterus cavity fluid, VEGF was decreased in CD9-/-TG compared with wild-type mice, so it was thought that loss of CD9 might interfere with VEGF production. When VEGF was injected in the uterine cavity of CD9 knockout mice, the endometrium was re-epithelialization. CD9 contributed to secretion of VEGF from endometrial epithelial cells, and these results provided the first evidence that CD9-mediated VEGF secretion plays a role in re-epithelialization of the uterus.
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研究種目 : 基盤研究(C)
研究期間 : 2011～2013
課題番号 : 23592413
研究分野 : 医歯薬学
科研費の分科・細目 : 外科系臨床医学・産婦人科学
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