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jkup2006_1_077.pdf
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Title |
Title |
Synthesis of novel amino acid-type fullerenes and their inhibition activity of HIV reverse transcriptase and HCV RNA polymerase
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Creator |
Name |
中村, 成夫
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Kana |
ナカムラ, シゲオ
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Romanization |
Nakamura, Shigeo
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Affiliation |
Department of Bioorganic and Medicinal Chemistry, Kyoritsu University of Pharmacy
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Affiliation (Translated) |
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Link |
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Name |
Ikegami, Noriko
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Kana |
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Romanization |
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Affiliation |
Department of Bioorganic and Medicinal Chemistry, Kyoritsu University of Pharmacy
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Affiliation (Translated) |
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Role |
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Link |
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Name |
Harada, Manami
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Kana |
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Romanization |
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Affiliation |
Department of Bioorganic and Medicinal Chemistry, Kyoritsu University of Pharmacy
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Name |
下遠野, 久美子
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Kana |
シモトオノ, クミコ
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Romanization |
Shimotohno, Kumiko
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Affiliation |
Department of Basic Biological Sciences, Kyoritsu University of Pharmacy
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Affiliation (Translated) |
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Link |
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Name |
高橋, 恭子
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Kana |
タカハシ, キョウコ
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Romanization |
Takahashi, Kyoko
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Affiliation |
Department of Bioorganic and Medicinal Chemistry, Kyoritsu University of Pharmacy
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Name |
増野, 匡彦
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Kana |
マシノ, タダヒコ
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Romanization |
Mashino, Tadahiko
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Affiliation |
Department of Bioorganic and Medicinal Chemistry, Kyoritsu University of Pharmacy
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Publisher |
Name |
共立薬科大学
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Kana |
キョウリツ ヤッカ ダイガク
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Romanization |
Kyoritsu yakka daigaku
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Date |
Issued (from:yyyy) |
2006
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Physical description |
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Source Title |
Name |
共立薬科大学雑誌
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Name (Translated) |
The journal of Kyoritsu University of Pharmacy
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Volume |
1
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Issue |
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Year |
2006
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Month |
3
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Start page |
77
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End page |
84
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Abstract |
We synthesized novel fullerene derivatives with amino, carboxylic, and ethyl ester groups. The HIV reverse transcriptase (HIV-RT) inhibition activities of these derivatives were higher than those of nevirapine, a clinically used HIV-RT inhibitor. However, they were less effective than those of the tricarboxylic derivative previously reported by our group, and the numbers of carboxylic groups did not affect the HIV-RT inhibition activity. Some derivatives have HCV RNA polymerase (HCV-RP) inhibition activities as well. Further optimization of the structure of the fullerene derivatives is required.
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Departmental Bulletin Paper
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