| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_26461594seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:284.7 KB
|
| Last updated |
:Nov 12, 2018 |
| Downloads |
: 345 |
Total downloads since Nov 12, 2018 : 345
|
|
| Release Date |
|
| Title |
| Title |
臨床検査応用を目指した小児慢性期CMLに対するフローサイトメトリー法の開発
|
| Kana |
リンショウ ケンサ オウヨウ オ メザシタ ショウニ マンセイキ CML ニ タイスル フローサイトメトリーホウ ノ カイハツ
|
| Romanization |
Rinshō kensa ōyō o mezashita shōni manseiki CML ni taisuru furōsaitometorīhō no kaihatsu
|
|
| Other Title |
| Title |
Flow cytometric analysis to predict prognosis in children with chronic-phase CML treated with imatinib
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
嶋, 晴子
|
| Kana |
シマ, ハルコ
|
| Romanization |
Shima, Haruko
|
| Affiliation |
慶應義塾大学・医学部(信濃町)・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 80424167
|
| Name |
嶋田, 博之
 |
| Kana |
シマダ, ヒロユキ
|
| Romanization |
Shimada, Hiroyuki
|
| Affiliation |
慶應義塾大学・医学部(信濃町)・講師
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 80265868
|
| Name |
清河, 信敬
|
| Kana |
キヨカワ, ノブタカ
|
| Romanization |
Kiyokawa, Nobutaka
|
| Affiliation |
国立研究開発法人国立成育医療研究センター・小児血液・腫瘍研究部・部長
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 60195401
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2018
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2017
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
18歳未満の新規慢性期CMLを対象に, 初発時およびTKI治療中の骨髄検体を用いてフローサイトメトリーで細胞表面マーカーを解析した。
診断時およびTKI開始後3か月時の骨髄検体に加え, TKI開始後3か月および18か月時のBCR-ABL/ABL比が得られた27例について解析した。その結果, 初発時骨髄前駆細胞分画におけるGMP優位, およびTKI開始3か月時のLin－CD34+分画中cMpl+分画高値が小児慢性期CMLの新たな予後因子となる可能性が示唆された。フローサイトメトリーは簡便な検査法であり, 広く活用されることが期待される。
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells (HSCs). This study aimed to investigate novel prognostic factor of CML using flow cytometry. Bone marrow samples of newly diagnosed children with chronic-phase CML were obtained at diagnosis and after imatinib initiation and stained with anti-human CD34, CD38, CD123, CD45RA, cMpl, and lineage antibodies. Flow cytometric analysis revealed that granulocyte macrophage progenitor predominance in CML progenitors at diagnosis and cMpl elevated expression in bone marrow progenitors at 3 months may predict poor outcome in children with chronic-phase CML treated with imatinib. We recommend flow cytometric analysis of bone marrow in the early phase of treatment, as it is a convenient tool that may predict treatment response and CML management.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究(C)(一般)
研究期間 : 2014～2017
課題番号 : 26461594
研究分野 : 小児血液腫瘍
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
