| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_26293081seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:437.1 KB
|
| Last updated |
:Sep 21, 2017 |
| Downloads |
: 1178 |
Total downloads since Sep 21, 2017 : 1178
|
|
| Release Date |
|
| Title |
| Title |
肝細胞癌の分子病理学的知見に基づくサブクラス分類の確立
|
| Kana |
カンサイボウガン ノ ブンシ ビョウリガクテキ チケン ニ モトズク サブクラス ブンルイ ノ カクリツ
|
| Romanization |
Kansaibogan no bunshi byorigakuteki chiken ni motozuku sabukurasu bunrui no kakuritsu
|
|
| Other Title |
| Title |
Establishing the molecular pathology-based subclassification of hepatocellular carcinoma.
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
坂元, 亨宇
 |
| Kana |
サカモト, ミチイエ
|
| Romanization |
Sakamoto, Michiie
|
| Affiliation |
慶應義塾大学・医学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 40221270
|
| Name |
福間, 真理子
|
| Kana |
フクマ, マリコ
|
| Romanization |
Fukuma, Mariko
|
| Affiliation |
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
| Name |
山﨑, 剣
|
| Kana |
ヤマザキ, ケン
|
| Romanization |
Yamazaki, Ken
|
| Affiliation |
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
| Name |
Effendi, Kathryn
|
| Kana |
エッフェンディー, カトリーヌ
|
| Romanization |
|
| Affiliation |
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2017
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2016
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
シグナル伝達系・表現型などの特徴を免疫組織学的に解析し, 悪性度も反映する肝細胞癌の新たなサブクラス分類を確立した。幹細胞・胆管上皮マーカーを発現する症例群では治療標的の候補であるMAPK経路の活性化やグリピカン3の高発現と関連することが, WNTシグナル経路が活性化した症例群はMRI画像診断により検出可能であることが示された。今後, これらの臨床応用が期待される。
By analyzing cell signaling features and phenotype immunohistochemically, a new subclassification of hepatocellular carcinoma (HCC) that reflects the degree of malignancy was established. Activated MAPK signaling or overexpression of Glypican 3 as therapeutic target candidates were shown in biliary/stem cell marker-positive HCCs. The use of MRI to diagnose HCC with activated WNT signaling was also revealed. These findings are expected to be applied in the clinical practice.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究(B)(一般)
研究期間 : 2014～2016
課題番号 : 26293081
研究分野 : 分子病理学, 肝臓病理学, 細胞生物学(浸潤・転移)
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
