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KAKEN_25861704seika.pdf
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| Title |
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表皮細胞の抗張力反応の解析
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| Kana |
ヒョウヒ サイボウ ノ コウチョウリョク ハンノウ ノ カイセキ
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Hyohi saibo no kochoryoku hanno no kaiseki
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Analysis of the tensile strength response in epidermal cell
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加藤, 達也
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カトウ, タツヤ
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Kato, Tatsuya
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 60641321
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2017
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科学研究費補助金研究成果報告書
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2016
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| Abstract |
マウス持続的抗張力負荷モデルにおけるケロイド様組織においてTissue inhibitor of metalloprotease-2(TIMP2)の低下を認めた。また表皮細胞においてはsmooth muscle actin(SMA)が抗張力負荷により表皮細胞において発現していた。塩基性線維芽細胞増殖因子を投与したところ, SMA発現は抑制される一方で, TIMP2の発現の低下は認められなった。すなわち抗張力を受けた細胞はその力に拮抗するために, SMAを発現させ, さらに組織として強固なものとするために線維芽細胞がコラーゲンを生成する可能性が示唆された。
A decrease in Tissue inhibitor of metalloprotease-2 (TIMP2) was observed in keloid-like tissues in a mouse persistent tensile loading model. In epidermal cells, smooth muscle actin (SMA) was expressed by tensile strength. Administration of basic fibroblast growth factor suppressed expression of SMA, but decreased expression of TIMP2 was observed. In other words, epidermal cells subjected to tensile strength expressed SMA to antagonize the force. Furthermore, it was suggested that fibroblasts produced collagen to obtain further strengthen.
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研究種目 : 若手研究(B)
研究期間 : 2013～2016
課題番号 : 25861704
研究分野 : 形成外科
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