| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_24659103seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:252.9 KB
|
| Last updated |
:Dec 11, 2014 |
| Downloads |
: 1567 |
Total downloads since Dec 11, 2014 : 1567
|
|
| Release Date |
|
| Title |
| Title |
非可逆性糖尿病性胃麻痺に対する神経幹細胞移植の開発
|
| Kana |
ヒカギャクセイ トウニョウビョウセイ イ マヒ ニ タイスル シンケイ カンサイボウ イショク ノ カイハツ
|
| Romanization |
Hikagyakusei tonyobyosei i mahi ni taisuru shinkei kansaibo ishoku no kaihatsu
|
|
| Other Title |
| Title |
Neural stem cell transplantation for refractory idiopathic or diabetic gastroparesis
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
鈴木, 秀和
|
| Kana |
スズキ, ヒデカズ
|
| Romanization |
Suzuki, Hidekazu
|
| Affiliation |
慶應義塾大学・医学部・准教授
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 70255454
|
| Name |
浦岡, 俊夫
|
| Kana |
ウラオカ, トシオ
|
| Romanization |
Uraoka, Toshio
|
| Affiliation |
慶應義塾大学・医学部・講師
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 80448216
|
| Name |
河瀬, 聡
|
| Kana |
カワセ, サトシ
|
| Romanization |
Kawase, Satoshi
|
| Affiliation |
慶應義塾大学・医学部・特任助教
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 80468496
|
| Name |
矢作, 直久
 |
| Kana |
ヤハギ, ナオヒサ
|
| Romanization |
Yahagi, Naohisa
|
| Affiliation |
慶應義塾大学・医学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 90292937
|
| Name |
福原, 誠一郎
|
| Kana |
フクハラ, セイイチロウ
|
| Romanization |
Fukuhara, Seiichiro
|
| Affiliation |
慶應義塾大学・医学部・大学院生
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
| Name |
正岡, 建洋
|
| Kana |
マサオカ, タツヒロ
|
| Romanization |
Masaoka, Tastuhiro
|
| Affiliation |
慶應義塾大学・医学部・助教
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
| Name |
内田, 勝幸
|
| Kana |
ウチダ, マサユキ
|
| Romanization |
Uchida, Masayuki
|
| Affiliation |
明治乳業研究所・食機能科学研究所・リーダー
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
| Name |
西村, 空也
|
| Kana |
ニシムラ, ソラヤ
|
| Romanization |
Nishimura, Soraya
|
| Affiliation |
慶應義塾大学・医学部・大学院生
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2014
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2013
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
糖尿病発症db/dbマウスの27%で胃排出が延長した。胃排出遅延db/dbマウスで胃筋間神経叢のnNOSとGFAP発現が低下した。胃排出遅延db/dbマウスで血清ApoE値が有意に低下した。ApoE KOマウスでは胃排出が低下し、胃排出遅延db/dbマウスと同様、筋間神経叢のnNOSやGFAP発現が低下した。nNOS KOマウス、ApoE KOマウスに神経幹細胞移植6週後の胃排出能は移植前に比べ有意に改善した。ApoE KOマウスでnNOSとGFAP発現は有意に回復した。本研究は神経幹細胞移植が胃運動不全麻痺で胃排出遅延を是正し、血清ApoEが消化管運動障害のマーカーとなることが示唆された。
Delayed gastric emptying was observed in 27 % of db/db mouse with a significant decrease in the serum ApoE level and in the myenteric nNOS and GFAP expression. The gastric emptying was also significantly delayed in ApoE knockout (KO) mouse with a decrease in the expression of nNOS and GFAP in myenteric plexus. Transplantation of neural stem cells (NSCs) improved delayed gastric emptying in nNOS KO mice and ApoE KO mise. The expressions of nNOS and GFAP in myenteric plexus were restored by transplantation of NSCs. Transplantation of NSCs restored the delayed gastric emptying in apoE knockout mice, suggesting a promising application of regenerative therapy against gastroparesis and a possible development of serum ApoE as a potential biomarker for gastrointestinal motility disorders.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 挑戦的萌芽研究
研究期間 : 2012～2013
課題番号 : 24659103
研究分野 : 医歯薬学
科研費の分科・細目 : 基礎医学・生理学一般
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
