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KAKEN_19K22568seika.pdf
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Download
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:494.1 KB
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:May 17, 2022 |
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Total downloads since May 17, 2022 : 494
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癌細胞シグナル活性化因子14-3-3ζを標的とした新規膵臓癌治療薬の開発
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| Kana |
ガン サイボウ シグナル カッセイカ インシ 14-3-3ζ オ ヒョウテキ ト シタ シンキ スイゾウガン チリョウヤク ノ カイハツ
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Gan saibō shigunaru kasseika inshi 14-3-3ζ o hyōteki to shita shinki suizōgan chiryōyaku no kaihatsu
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Development of new therapeutic agents for pancreatic cancer targeting 14-3-3dzeta
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佐谷, 秀行
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サヤ, ヒデユキ
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Saya, Hideyuki
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慶應義塾大学・医学部 (信濃町) ・教授
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Research team head
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科研費研究者番号 : 80264282
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齋藤, 潤
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サイトウ, ジュン
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Saitō, Jun
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慶應義塾大学・医学部 (信濃町) ・共同研究員
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Research team member
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科研費研究者番号 : 80837378
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2021
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科学研究費補助金研究成果報告書
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2020
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申請者は数年前よりBenzaldehyde（BA）という芳香族アルデヒドのがん細胞抑制効果に注目してその作用機序の解明を行ってきた。その結果、BAは正常細胞には細胞傷害性をほとんど示さず、膵臓がん細胞BxPC3、肺がん細胞株A549などに対して顕著な腫瘍抑制効果を示し、その機構として14-3-3ζがクライアント蛋白のリン酸化部分に結合するのを阻害することを見出した。本研究では、分子標的薬や放射線治療に耐性になった細胞では14-3-3ζの標的であるAxlが上昇することに着目し、その発現をBAが抑制することで耐性克服効果があることを見出した。
We have been elucidating the mechanism of action by focusing on the cancer cell-suppressing effect of aromatic aldehyde called Benzaldehyde (BA) for several years. As a result, BA showed no cytotoxicity to normal cells and showed a remarkable tumor suppressive effect on pancreatic cancer cell BxPC3, lung cancer cell line A549, etc. BA was found to inhibit the binding of 14-3-3ζ to the phosphorylated moiety of its client protein. In this study, we focused on Axl, which is one of the client proteins of 14-3-3ζ, because Axl is increased in cells which become resistant to molecular-targeted drugs and radiotherapy. We found that BA suppresses Axl expression and may have a tolerance-overcoming effect.
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研究種目 : 挑戦的研究 (萌芽)
研究期間 : 2019～2020
課題番号 : 19K22568
研究分野 : 腫瘍生物学
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