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KAKEN_18K16779seika.pdf
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Title |
Title |
骨盤内膿瘍に対するMRスペクトロスコピーとNGSを用いた新たな診断治療法の構築
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コツバンナイ ノウヨウ ニ タイスル MR スペクトロスコピー ト NGS オ モチイタ アラタナ シンダン チリョウホウ ノ コウチク
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Kotsubannai nōyō ni taisuru MR supekutorosukopī to NGS o mochiita aratana shindan chiryōhō no kōchiku
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Exploratory research for new methodology of diagnosis and treatments of gynecological pelvic abscess using MR spectroscopy and Identification of bacteria species by NGS
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野上, 侑哉
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ノガミ, ユウヤ
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Nogami, Yūya
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慶應義塾大学・医学部 (信濃町) ・共同研究員
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Research team head
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科研費研究者番号 : 90574294
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阪埜, 浩司
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バンノ, コウジ
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Banno, Kōji
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Collaborator
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科研費研究者番号 : 70265875
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奥田, 茂男
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オクダ, シゲオ
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Okuda, Shigeo
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Collaborator
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科研費研究者番号 : 30233456
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2020
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科学研究費補助金研究成果報告書
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2019
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骨盤内膿瘍は深部にあるため、培養検査が行ないにくく、検査のないまま治療が始められることが多い。そのまま改善する例もあるが、一定期間経過をみて改善がなければ、穿刺など侵襲的処置が必要となり、結果的に治療期間が延長するため、治療開始時に始めから穿刺の要否が予想できればメリットがある。また培養検査が行なえても、先行抗菌薬の影響や培養されにくい菌などあり、原因菌がわからないことも多い。
治療開始時のMRSから予想できないか検討した。リンパ嚢胞感染症例に限れば穿刺の要否が予想しうる可能性が示唆された。菌種の予想は難しかった。菌種同定にNGSを用いると、培養検査では不明であった原因菌が全症例で同定できた。
Pelvic abscesses are challenging to puncture because of its location in deep pelvis and the treatments are started without culture examination in most cases. Some cases are improved conservatively. Otherwise, invasive procedure such as drainage will be needed after expectant management, and it results in prolongation of duration of therapy. The examination which can predict the necessity of drainage in start will give merits.Even when the culture test was performed, causative bacteria are still unknown in some cases, because of proceeding antibiotics and culture difficulty of anaerobic bacteria.
We investigated that the necessity of drainage and bacteria species are predictable or not using MRS. In lymphocele infection cases, necessity of drainage was indicated to be predictable. It was difficult to predict bacteria species. Identification bacteria species using NGS could revealed the causative bacteria in all cases, even in case which culture test was false negative.
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研究種目 : 若手研究
研究期間 : 2018~2019
課題番号 : 18K16779
研究分野 : 婦人科感染症
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Mar 5, 2021 | | インデックス を変更 |
Nov 15, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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