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KAKEN_18K06067seika.pdf
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Download
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:75.7 KB
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| Last updated |
:May 17, 2022 |
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Total downloads since May 17, 2022 : 165
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神経幹細胞の分化能を規定するDNAメチル化変動の解明
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シンケイ カンサイボウ ノ ブンカノウ オ キテイスル DNA メチルカ ヘンドウ ノ カイメイ
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Shinkei kansaibō no bunkanō o kiteisuru DNA mechiruka hendō no kaimei
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Analysis of DNA methylation changes that determine the differentiation potential of neural stem cells
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佐野坂, 司
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サノサカ, ツカサ
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Sanosaka, Tsukasa
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 40588472
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2021
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科学研究費補助金研究成果報告書
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2020
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神経幹細胞は自己複製能を持つと同時に、脳・神経系を構成するニューロン、アストロサイト、オリゴデンドロサイトへの多分化能を持った細胞である。しかしながら神経幹細胞は発生初期には多分化能を持たず、発生進行に伴い順次上述細胞種への分化能を獲得する。本研究課題では、DNAメチル化というエピジェネティックな修飾に着目し、神経幹細胞の分化能の変化を解析した。その結果、３つのステップによりメチル化状態がダイナミックに変動し、各細胞種への分化能を獲得していることが明らかとなった。
Neural stem cells are cells that have self-renewal ability and have potential to differentiate into neurons, astrocytes, and oligodendrocytes that make up the brain and nervous system. However, neural stem cells do not have pluripotency in the early stage of development, and gradually acquire the ability to differentiate into the above-mentioned cell types as development progresses. In this research project, we focused on the epigenetic modification of DNA methylation and analyzed changes in the differentiation potential of neural stem cells. As a result, it was clarified that the methylation state dynamically fluctuates by three steps and the ability to differentiate into each cell type is acquired.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K06067
研究分野 : 神経科学
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