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KAKEN_17K16095seika.pdf
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尿細管MR機能との比較を通じた腸管MRの血圧代謝関連病態における新たな意義の解明
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ニョウ サイカン MR キノウ トノ ヒカク オ ツウジタ チョウカン MR ノ ケツアツ タイシャ カンレン ビョウタイ ニ オケル アラタナ イギ ノ カイメイ
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Nyō saikan MR kinō tono hikaku o tsūjita chōkan MR no ketsuatsu taisha kanren byōtai ni okeru aratana igi no kaimei
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Elucidation of novel intestinal MR function in hypertension and metabolism associated disorder
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中村, 俊文
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ナカムラ, トシフミ
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Nakamura, Toshifumi
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慶應義塾大学・医学部 (信濃町)・共同研究員
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Research team head
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科研費研究者番号 : 10594583
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2019
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科学研究費補助金研究成果報告書
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2018
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腸管上皮特異的なミネラルコルチコイド受容体 (MR) 欠損マウス (腸MR-KO) では便中Na排泄の増加と尿中Na排泄の抑制が見られた。対照的に尿細管特異的なMR欠損マウスでは尿中Na排泄が増加する一方で便中Na排泄が抑制されており、腸MR・腎MRのそれぞれが生体のNa恒常性に深く関与し、相補的に機能していることが示された。また、Controlマウスへの高脂肪食負荷では通常食に比較し体重・血圧・尿中アルブミン・MR標的遺伝子発現の増加が見られ、腸MR-KOではその増加が抑制される傾向にあった。本研究から、腸MRがNa恒常性のみならず代謝機能や臓器障害にまで広く関与する可能性が示唆された。
Intestinal epithelial cells-specific mineralocorticoid receptor knockout (IEC-MR KO) mice showed significantly increased fecal Na excretion and accompanied reduced urinary Na excretion. In contrast, increased urinary Na excretion in renal tubular cells-specific MR knockout mice was compensated by suppression of fecal Na excretion. These results show that both intestinal MR and renal MR play essential roles in Na homeostasis and have mutual complementary relationship. In addition, compared to normal diet, high fat diet elevated blood pressure and increased body weight, urinary albumin and the expression of MR target genes in control mice. These changes tended to be attenuated in IEC-MR KO mice. This study suggests that intestinal MR is not only associated with Na homeostasis but also has a potential to affect the metabolic function and organ disorders.
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研究種目 : 若手研究(B)
研究期間 : 2017～2018
課題番号 : 17K16095
研究分野 : 腎臓学
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| Oct 31, 2019 | | インデックス を変更 |
| Aug 23, 2023 | | Creator,Abstract 内容,Note 注記 を変更 |
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