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KAKEN_17K15655seika.pdf
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:May 17, 2022 |
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肝細胞癌サブクラス分類が悪性度を反映する機序の解明と診断への応用
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カンサイボウガン サブクラス ブンルイ ガ アクセイド オ ハンエイスル キジョ ノ カイメイ ト シンダン エノ オウヨウ
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kansaibōgan sabukurasu bunrui ga akuseido o han'eisuru kijo no kaimei to shindan eno ōyō
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Research of useful molecular markers for hepatocellular carcinoma subclassfication and the application to pathological diagnosis
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辻川, 華子
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ツジカワ, ハナコ
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Tsujikawa, Hanako
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 30528170
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2021
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科学研究費補助金研究成果報告書
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2020
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肝細胞癌におけるERK核内発現強度・割合に基づき3群に分類したところ、ERK活性化肝細胞癌は血清α フェトプロテイン高値で低分化であり、脈管侵襲が多く、Cytokeratin19や SALL4等の胆管上皮/幹細胞マーカー, 細胞増殖や癌の悪性化に関連するとされるc-MET, 細胞増殖を反映するKi-67の高発現を呈し、高悪性度とされる胆管上皮/幹細胞マーカー陽性群に多く見られた。
また肝細胞癌の腫瘍内コラーゲンおよびエラスチン線維の定量解析を行い、臨床病理放射線学的に検討したところ、腫瘍内線維に富む肝細胞癌は、胆管上皮/幹細胞マーカー陽性群に多く見られた。
Hepatocellular carcinoma (HCC) were classified into three groups based on the intensity and ratio of ERK nuclear expression. ERK-activated hepatocellular carcinoma is poorly differentiated with high serum alpha-fetoprotein levels, high vascular invasion, and high expression of Cytokeratin19 and SALL4, c-MET, ki-67, which is associated with cell proliferation and tumor malignancy.
Quantitative analysis of intratumoral collagen and elastin fibers in HCC and clinico-pathoradiological study showed that stromal fiber-rich HCC were significantly associated with the biliary/stem cell markers-positive HCC subtype and likely represent a distinct clinico-pathoradiological entity.
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研究種目 : 若手研究 (B)
研究期間 : 2017～2020
課題番号 : 17K15655
研究分野 : 肝細胞癌
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