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KAKEN_17K11410seika.pdf
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Download
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:356.9 KB
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:Nov 15, 2022 |
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Total downloads since Nov 15, 2022 : 335
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| Title |
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低酸素応答因子を標的とした頭頸部癌転移治療の開発
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テイサンソ オウトウ インシ オ ヒョウテキ ト シタ トウケイブガン テンイ チリョウ ノ カイハツ
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Teisanso ōtō inshi o hyōteki to shita tōkeibugan ten'i chiryō no kaihatsu
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Development of head and neck cancer treatment targeting HIF1-alpha
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小澤, 宏之
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オザワ, ヒロユキ
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Ozawa, Hiroyuki
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 30327621
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中原, 奈々
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ナカハラ, ナナ
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Nakahara, Nana
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慶應義塾大学・医学部 (信濃町) ・助教
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Collaborator
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御子柴, 卓弥
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ミコシバ, タクヤ
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Mikoshiba, Takuya
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慶應義塾大学・医学部 (信濃町) ・助教
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Collaborator
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2020
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科学研究費補助金研究成果報告書
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2019
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| Abstract |
HIF1-α転写因子の1つであるANGPTL4と頭頸部癌との関わりについて検討した。
下咽頭癌症例のANGPTL4の免疫組織学的発現と臨床所見との関連について検討した。多変量解析で、OSについてANGPTL4発現が独立した予後規定因子であった。中咽頭癌でも同様の結果が得られた。
続いて、頭頸部癌細胞株を用いANGPTL4発現のノックダウンを行い、ANGPTL4発現を低下すると、EMT関連遺伝子やがん幹細胞形質に関連する遺伝子の発現が減少した。ANGPTL4は腫瘍の促進と抑制と双方に関わっている報告があるが、頭頸部癌ではANGPTL4は腫瘍を抑制する方向で働いていることが示された。
We investigated the association of ANGPTL4, one of the HIF1-α transcription factors, with head and neck cancer.
We examined the immunohistological expression of ANGPTL4 in hypopharyngeal carcinoma cases and its association with clinical data. Multivariate analysis revealed that ANGPTL4 expression was an independent prognostic determinant for overall survival. Similar results were obtained for oropharyngeal carcinoma patients.
Subsequent knockdown of ANGPTL4 expression in head and neck cancer cell lines showed that the down-regulation of ANGPTL4 reduced the expression of EMT-associated genes and genes associated with cancer stem cell properties. These results indicated that ANGPTL4 has a possibility to act as a tumor suppressor in head and neck cancers, although ANGPTL4 has been reported to be involved in both tumor promotion and suppression.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017～2019
課題番号 : 17K11410
研究分野 : 頭頸部外科
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| Mar 5, 2021 | | インデックス を変更 |
| Nov 15, 2022 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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