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KAKEN_17K09961seika.pdf
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Download
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:248.6 KB
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:Mar 5, 2021 |
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同種造血細胞移植後ヒトヘルペスウイルス6型再活性化の免疫機構の解明と予防法の確立
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ドウシュ ゾウケツ サイボウ イショクゴ ヒト ヘルペス ウイルス 6ガタ サイカッセイカ ノ メンエキ キコウ ノ カイメイ ト ヨボウホウ ノ カクリツ
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Dōshu zōketsu saibō ishokugo hito herupesu uirusu 6gata saikasseika no men'eki kikō no kaimei to yobōhō no kakuritsu
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Human Herpes Virus 6 reactivation after allogeneic stem cell transplantation
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山崎, 理絵
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ヤマザキ, リエ
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Yamazaki, Rie
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 80365262
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中山, 瞳
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ナカヤマ, ヒトミ
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Nakayama, Hitomi
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Collaborator
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2020
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科学研究費補助金研究成果報告書
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2019
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同種移植患者34例の血漿中のHHV-6DNA量をデジタルPCR及びリアルタイムPCRで測定し、CD4+ T細胞におけるCD134 (HHV-6特異的受容体) 発現率とHHV-6再活性化の関連を前向きに検討した。HHV-6再活性化群では非再活性化群に比し移植前のCD4+ T細胞におけるCD134発現率 (CD134/CD4比) が有意に高値だった (3.8% vs 1.5%, P<0.01) 。多変量解析にて移植前CD134/CD4比高値 (odds比=10.5, P=0.03) と臍帯血を含むHLA不適合移植 (odds比=15.4, P=0.04) がHHV-6再活性化のリスク因子であることを示した。
We prospectively evaluated the relationship between HHV-6 reactivation and CD134+ T cells in the recipients of allo-HSCT.
HHV-6 viral load in plasma was quantitatively measured weekly after allo-HSCT by digital PCR in 34 patients. The ratio of CD134 in CD4+ T cells (CD134/CD4 ratio) was serially measured by flow cytometry before and after HSCT. The CD134/CD4 ratio before HSCT was significantly higher in patients with HHV-6 reactivation than in those without (median, 3.8% vs 1.5%, P<0.01). In the multivariate analysis, a higher CD134/CD4 ratio before conditioning (odds ratio [OR], 10.5, P=0.03) and a stem cell source from an HLA-mismatched donor (OR, 15.4, P=0.04) remained as significant factors associated with HHV-6 reactivation.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017～2019
課題番号 : 17K09961
研究分野 : 造血幹細胞移植
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