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KAKEN_17K08548seika.pdf
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:82.1 KB
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:Mar 5, 2021 |
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軟骨原基を形成する形態形成関連因子の三次元的解析
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ナンコツ ゲンキ オ ケイセイスル ケイタイ ケイセイ カンレン インシ ノ サンジゲンテキ カイセキ
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Nankotsu genki o keiseisuru keitai keisei kanren inshi no sanjigenteki kaiseki
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Three-dimensional analysis of morphogenetic factors forming cartilage primordia
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依田, 昌樹
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ヨダ, マサキ
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Yoda, Masaki
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慶應義塾大学・医学部 (信濃町) ・特任助教
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Research team head
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科研費研究者番号 : 30464994
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2020
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科学研究費補助金研究成果報告書
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2019
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軟骨原基が形成される時期は間葉系組織中に血管の侵入はないことから、軟骨原基の形態形成関連因子を産生しているのは軟骨原基周囲の間葉系細胞であると考えられる。胎生期の軟骨原基および周囲に存在する間葉系細胞の可視化をおこなった結果、軟骨原基の発現が部位ごとに異なることが分かった。また、組織学的観察により軟骨原基と周囲の細胞群の境界面にPDGFRα陽性細胞の局在が明らかとなり、成長因子であるPDGFの関与が示唆された。三次元的解析から軟骨を可視化できることができ、今後の免疫染色を併用した形態形成因子の局在解明に関する知見が得られた。
Since there is no invasion of blood vessels into the mesenchymal tissues at the time when the cartilage primordia are formed, it is suggested that the mesenchymal cells around the cartilage primordia are producing the morphogenetic factors related to the cartilage primordia. As a result of visualizing the cartilage primordia in the embryonic period and surrounding mesenchymal cells, it was found that the expression of cartilage primordia was different in each site. Moreover, histological observation revealed the localization of PDGFRα-positive cells at the interface between the cartilage primordia and the surrounding cell group, suggesting the involvement of PDGF. The cartilage could be visualized from the three-dimensional analysis, and the findings regarding the localization elucidation of morphogenetic factors using immunostaining were obtained.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017～2019
課題番号 : 17K08548
研究分野 : 整形外科学
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