がんの早期発見方法や標準的治療法の確立、新しい分子標的薬の登場など、診断・治療技術の進歩はがん治療成績の向上をもたらしつつあるが、いまだ十分とは言えない。本研究では、消化器がんに影響を及ぼすことが知られている高濃度胆汁酸のみならず、肝障害やがんによる胆管の閉塞、その他の理由により血液中で上昇する濃度範囲の胆汁酸上昇 (消化管中に流れ込む胆汁酸よりも低濃度) が、がん細胞の種類や胆汁酸に曝露される濃度や環境により、がん細胞の増殖を促進し、抗がん剤の抗腫瘍効果を低下させる可能性を明らかにした。
Recently, many standard-of-care chemotherapy regimens have been established and new approaches to improve the prevention and early detection of cancer have also been developed. However, unfortunately, they leave much to be desired.
In this study, we focused on the cancer treatments of patients with conditions like cholestasis. As a first step of this study, we mainly used several human cancer cells and deoxycholate (DCA) or chenodeoxycholate (CDCA) which are components in bile acids. We showed that DCA and / or CDCA with concentrations corresponding to elevated serum levels in such as cholestasis or biliary obstruction by tumors enhanced cell proliferation and / or decreased sensitivity to anticancer drugs depending on the kinds of cancer cells and conditions of bile acids exposure.

研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017～2019
課題番号 : 17K08424
研究分野 : 医療薬学